Haploidentical donors are now increasingly considered for transplantation in the absence of
HLA-matched donors or when an urgent transplant is needed. Donor-specific anti-HLA …

Introduction: One significant obstacle to the success of allogeneic hematopoietic stem cell
transplantation (HSCT) is represented by graft failure, defined as either lack of initial …

Detection of donor-specific anti-HLA antibodies (DSA) has been associated with graft
rejection in all forms of transplantation. The mechanism by which DSA increase the risk of …

Background. Although donor-specific anti-human leukocyte antigen (HLA) antibodies (DSA)
have been implicated in graft rejection in solid organ transplantation, their role in …

Anti-HLA donor-specific Abs (DSAs) have been reported to be associated with graft failure in
mismatched hematopoietic stem cell transplantation; however, their role in the development …

Donor-specific anti-HLA antibodies (DSAs) are a major cause of engraftment failure in
patients receiving haploidentical stem cell transplantation (HaploSCT). Effective treatments …

Allogeneic hematopoietic stem cell transplantation (AHSCT) is a curative treatment for a
wide variety of hematological diseases. In 30% of the cases, a geno-identical donor is …

Although genetic induction of factor VIII (FVIII) expression in platelets can restore hemostasis
in hemophilia A mice, this approach has not been studied in the clinical setting of preexisting …

Outcomes of allogeneic hematopoietic stem cell transplantation (AHSCT) using HLA‐half
matched related donors (haploidentical) have recently improved due to better control of …

Desensitization protocols are being used worldwide to enable kidney transplantation across
immunologic barriers, ie antibody to donor HLA or ABO antigens, which were once thought …