[HTML][HTML] Chaperones directly and efficiently disperse stress-triggered biomolecular condensates

H Yoo, JAM Bard, EV Pilipenko, DA Drummond - Molecular Cell, 2022 - cell.com
Stresses such as heat shock trigger the formation of protein aggregates and the induction of
a disaggregation system composed of molecular chaperones. Recent work reveals that …

The inner workings of an ancient biological clock

M Fang, A LiWang, SS Golden, CL Partch - Trends in Biochemical Sciences, 2024 - cell.com
Circadian clocks evolved in diverse organisms as an adaptation to the daily swings in
ambient light and temperature that derive from Earth's rotation. These timing systems, based …

Nutritional compensation of the circadian clock is a conserved process influenced by gene expression regulation and mRNA stability

CM Kelliher, EL Stevenson, JJ Loros, JC Dunlap - PLoS Biology, 2023 - journals.plos.org
Compensation is a defining principle of a true circadian clock, where its approximately 24-
hour period length is relatively unchanged across environmental conditions. Known …

Network switches and their role in circadian clocks

M Del Olmo, S Legewie, M Brunner, T Höfer… - Journal of Biological …, 2024 - ASBMB
Circadian rhythms are generated by complex interactions among genes and proteins. Self-
sustained∼ 24 h oscillations require negative feedback loops and sufficiently strong …

Statistical data retrieval technique in astronomy computational physics

RC Siagian, P Pribadi, GHD Sinaga… - JATISI (Jurnal Teknik …, 2023 - jurnal.mdp.ac.id
Computational astronomy is a very important branch in today's era, where physicists or
researchers can use computers to process statistics in astronomical physics. researchers …

KidA, a multi-PAS domain protein, tunes the period of the cyanobacterial circadian oscillator

SJ Kim, C Chi, G Pattanayak… - Proceedings of the …, 2022 - National Acad Sciences
The cyanobacterial clock presents a unique opportunity to understand the biochemical basis
of circadian rhythms. The core oscillator, composed of the KaiA, KaiB, and KaiC proteins …

Evolution of the repression mechanisms in circadian clocks

J Tyler, Y Lu, J Dunlap, DB Forger - Genome Biology, 2022 - Springer
Background Circadian (daily) timekeeping is essential to the survival of many organisms. An
integral part of all circadian timekeeping systems is negative feedback between an activator …

Shift in conformational equilibrium underlies the oscillatory phosphoryl transfer reaction in the circadian clock

P Kim, N Thati, S Peshori, HI Jang, YI Kim - Life, 2021 - mdpi.com
Oscillatory phosphorylation/dephosphorylation can be commonly found in a biological
system as a means of signal transduction though its pivotal presence in the workings of …

Multimeric structure enables the acceleration of KaiB-KaiC complex formation induced by ADP/ATP exchange inhibition

S Koda, S Saito - PLOS Computational Biology, 2022 - journals.plos.org
Circadian clocks tick a rhythm with a nearly 24-hour period in a variety of organisms. In the
clock proteins of cyanobacteria, KaiA, KaiB, and KaiC, known as a minimum circadian clock …

A role for gene expression and mRNA stability in nutritional compensation of the circadian clock

CM Kelliher, EL Stevenson, JJ Loros, JC Dunlap - bioRxiv, 2022 - biorxiv.org
Compensation is a defining principle of a true circadian clock, where its approximately 24-
hour period length is relatively unchanged across environmental conditions. Known …