Portal hypertension develops as a result of increased intrahepatic vascular resistance often
caused by chronic liver disease that leads to structural distortion by fibrosis, microvascular …

The chemokine stromal cell-derived factor-1 (SDF-1) or CXCL12 is constitutively expressed
in healthy liver. However, its expression increases following acute or chronic liver injury …

Chemokine receptors are members of the G protein-coupled receptor superfamily, which
together with chemokine ligands form chemokine networks to regulate various cellular …

The liver is a common site for the metastatic spread of primary malignancies including
colorectal cancer, and liver metastasis is a main cause of death in cancer patients. This is …

SOCS8, also known as CISHb, is a fish-specific type II SOCS. Because CISH binds to
cytokine receptors and may inhibit STAT5 activation (a substrate of the insulin receptor) …

Background Chemokines contribute to the pathogenesis of autoimmune hepatitis by
directing the migration and positioning of inflammatory and immune cells within the liver …

This chapter reviews multiple aspects of hepatic fibrosis, including its pathophysiologic
mechanisms, natural history, clinical features, current and future tools for diagnosing fibrosis …

The activation and differentiation of cancer-associated fibroblasts (CAF) are involved in
tumor progression. Here, we show that the tumor-promoting lipid mediator prostaglandin E2 …

Hepatic fibrosis (HF) is the process of fibrous scar formation caused by chronic liver injury of
different etiologies. Previous studies have hypothesized that the activation of hepatic stellate …

An unprecedented spiro-C-glycoside adduct, heteryunine A (1), along with two uncommon
alkaloids featuring a 2, 3-diketopiperazine skeleton, heterpyrazines A (2) and B (3), were …