Chemokines (chemo‐attractant cytokines) are a group of small proteins that act together with
their cell surface receptors, in development, normal physiology and immune responses, to …

Thyroid carcinoma consists a group of phenotypically heterogeneous cancers. Recent
advances in biological technologies have been advancing the delineation of genetic …

Abstract The Crk adaptor proteins (Crk and CrkL) constitute an integral part of a network of
essential signal transduction pathways in humans and other organisms that act as major …

Acute myeloid leukemia (AML) cells are highly dependent on oxidative phosphorylation
(OxPhos) for survival, and they continually adapt to fluctuations in nutrient and oxygen …

Background The programmed cell death-1 (PD-1) receptor and its ligands PD-L1 and PD-L2
are immune checkpoints that suppress anti-cancer immunity. Typically, cancer cells express …

It has now been over 10 years since efforts to completely understand the signalling actions
of cAMP (3′‐5′‐cyclic adenosine monophosphate) led to the discovery of exchange …

We previously identified a region of recurrent amplification on chromosome 22q11. 21 in a
subset of primary lung adenocarcinomas. Here we show that CRKL, encoding for an adaptor …

Thyroid cancer is the most common type of endocrine malignancy, encompassing tumors
with various levels of invasive growth and aggressiveness. Rap1GAP, a Rap1 GTPase …

cAMP stimulates proliferation in many cell types. For many years, cAMP-dependent protein
kinase (PKA) represented the only known cAMP effector. PKA, however, does not fully mimic …

Rearranged during transfection (RET) rearrangement oncoprotein-mediated Ras/MAPK
signaling cascade is constitutively activated in cancers. Here, we demonstrate a unique …