Emerging technologies for the clinical microbiology laboratory
BW Buchan, NA Ledeboer - Clinical microbiology reviews, 2014 - Am Soc Microbiol
In this review we examine the literature related to emerging technologies that will help to
reshape the clinical microbiology laboratory. These topics include nucleic acid amplification …
reshape the clinical microbiology laboratory. These topics include nucleic acid amplification …
HIV-1 antiretroviral resistance: scientific principles and clinical applications
MW Tang, RW Shafer - Drugs, 2012 - Springer
The efficacy of an antiretroviral (ARV) treatment regimen depends on the activity of the
regimen's individual ARV drugs and the number of HIV-1 mutations required for the …
regimen's individual ARV drugs and the number of HIV-1 mutations required for the …
SARS-CoV-2 evolution during treatment of chronic infection
The spike protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
critical for virus infection through the engagement of the human ACE2 protein and is a major …
critical for virus infection through the engagement of the human ACE2 protein and is a major …
[HTML][HTML] Neutralising antibodies in Spike mediated SARS-CoV-2 adaptation
SARS-CoV-2 Spike protein is critical for virus infection via engagement of ACE2, and amino
acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are …
acid variation in Spike is increasingly appreciated. Given both vaccines and therapeutics are …
Identification of genetically intact HIV-1 proviruses in specific CD4+ T cells from effectively treated participants
Latent replication-competent HIV-1 persists in individuals on long-term antiretroviral therapy
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
(ART). We developed the Full-Length Individual Proviral Sequencing (FLIPS) assay to …
Specific HIV integration sites are linked to clonal expansion and persistence of infected cells
F Maldarelli, X Wu, L Su, FR Simonetti, W Shao, S Hill… - Science, 2014 - science.org
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into …
Extremely high mutation rate of HIV-1 in vivo
Rates of spontaneous mutation critically determine the genetic diversity and evolution of
RNA viruses. Although these rates have been characterized in vitro and in cell culture …
RNA viruses. Although these rates have been characterized in vitro and in cell culture …
Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir
JK Bui, MD Sobolewski, BF Keele, J Spindler… - PLoS …, 2017 - journals.plos.org
The major obstacle to curing HIV infection is the persistence of cells with intact proviruses
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
that can produce replication-competent virus. This HIV reservoir is believed to exist primarily …
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
The precise identification of the HIV-1 envelope glycoprotein (Env) responsible for
productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 …
productive clinical infection could be instrumental in elucidating the molecular basis of HIV-1 …
HIV rebound is predominantly fueled by genetically identical viral expansions from diverse reservoirs
Viral rebound upon stopping combined antiretroviral therapy poses a major barrier toward
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …
an HIV cure. Cellular and anatomical sources responsible for reinitiating viral replication …