Artemisinins are a family of sesquiterpene trioxane lactone anti-malarial agents originally
derived from Artemisia annua L. The anti-malarial action of artemisinins involves the …

Development of resistance to anthelmintic drugs is an increasing problem that decreases
the productivity of livestock and threatens the success of treatment in humans. It is essential …

Schistosomiasis is a helminthic disease affecting more than 200 million people in the tropics
as well as returning travellers. Treatment mainly relies on a single drug, praziquantel …

The antimalarial trioxanes, exemplified by the naturally occurring sesquiterpene lactone
artemisinin and its semi-synthetic derivatives, contain an endoperoxide pharmacophore that …

Although praziquantel (PZQ) has been used to treat schistosomiasis for over 20 years its
mechanism of action remains unknown. We have developed an assay based on the …

Parasitic helminths have a coexistence with mammalian hosts whereby they survive for
several years in known hostile conditions of their hosts. Many explanations exist describing …

Despite being one of the most commonly used drugs, the molecular mechanism of action of
the anthelmintic praziquantel remains unknown. There are some unusual features of this …

Drug-resistant pathogens emerge faster than new drugs come out of drug discovery
pipelines. Current and future drug options should therefore be better protected, requiring a …

Praziquantel (PZQ) is the drug of choice for schistosomiasis and probably is the only highly
effective drug currently available for treating schistosomiasis-infected individuals. The mode …

Benzimidazole drugs are used for treatment of trichinellosis, but they have a limited effect
against encapsulated larval stages of Trichinella spiralis. Hence, there is a considerable …