[PDF][PDF] In search of an osteoblast cell model for in vitro research
The process of bone formation, remodelling and healing involves a coordinated action of
various cell types. Advances in understanding the biology of osteoblast cells during these …
various cell types. Advances in understanding the biology of osteoblast cells during these …
[HTML][HTML] Molecular mechanisms of mesenchymal stem cell differentiation towards osteoblasts
Bone is a dynamic tissue that is constantly renewed by the coordinated action of two cell
types, ie., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in …
types, ie., the bone-resorbing osteoclasts and the bone-forming osteoblasts. However, in …
RUNX family: Oncogenes or tumor suppressors
BA Otálora‑Otálora, B Henríquez… - Oncology …, 2019 - spandidos-publications.com
Runt‑related transcription factor (RUNX) proteins belong to a transcription factors family
known as master regulators of important embryonic developmental programs. In the last …
known as master regulators of important embryonic developmental programs. In the last …
Epigenetic control of the bone-master Runx2 gene during osteoblast-lineage commitment by the histone demethylase JARID1B/KDM5B
Transcription factor Runx2 controls bone development and osteoblast differentiation by
regulating expression of a significant number of bone-related target genes. Here, we report …
regulating expression of a significant number of bone-related target genes. Here, we report …
The secreted protein DEL-1 activates a β3 integrin–FAK–ERK1/2–RUNX2 pathway and promotes osteogenic differentiation and bone regeneration
The integrin-binding secreted protein developmental endothelial locus-1 (DEL-1) is involved
in the regulation of both the initiation and resolution of inflammation in different diseases …
in the regulation of both the initiation and resolution of inflammation in different diseases …
Tgfβ1 suppressed matrix mineralization of osteoblasts differentiation by regulating SMURF1–C/EBPβ–DKK1 axis
B Nam, H Park, YL Lee, Y Oh, J Park, SY Kim… - International Journal of …, 2020 - mdpi.com
Transforming growth factor β1 (TGFβ1) is a major mediator in the modulation of osteoblast
differentiation. However, the underlying molecular mechanism is still not fully understood …
differentiation. However, the underlying molecular mechanism is still not fully understood …
The specification of cortical subcerebral projection neurons depends on the direct repression of TBR1 by CTIP1/BCL11a
J Cánovas, FA Berndt, H Sepúlveda… - Journal of …, 2015 - Soc Neuroscience
The acquisition of distinct neuronal fates is fundamental for the function of the cerebral
cortex. We find that the development of subcerebral projections from layer 5 neurons in the …
cortex. We find that the development of subcerebral projections from layer 5 neurons in the …
Ezh1 and Ezh2 differentially regulate PSD-95 gene transcription in developing hippocampal neurons
Abstract Polycomb Repressive Complex 2 (PRC2) mediates transcriptional silencing by
catalyzing histone H3 lysine 27 trimethylation (H3K27me3), but its role in the maturation of …
catalyzing histone H3 lysine 27 trimethylation (H3K27me3), but its role in the maturation of …
[HTML][HTML] Celecoxib inhibits osteoblast maturation by suppressing the expression of Wnt target genes
A Nagano, M Arioka, F Takahashi-Yanaga… - Journal of …, 2017 - Elsevier
Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to impair bone healing.
We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID …
We previously reported that in colon cancer cells, celecoxib, a COX-2-selective NSAID …
Cancer–Osteoblast Interaction Reduces Sost Expression in Osteoblasts and Up-Regulates lncRNA MALAT1 in Prostate Cancer
Dynamic interaction between prostate cancer and the bone microenvironment is a major
contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co …
contributor to metastasis of prostate cancer to bone. In this study, we utilized an in vitro co …