Specific chemical modifications of biological molecules are an efficient way of regulating
molecular function, and a plethora of downstream signalling pathways are influenced by the …

Among all tumor suppressor microRNAs, reduced let-7 expression occurs most frequently in
cancer and typically correlates with poor prognosis. Activation of either LIN28A or LIN28B …

Effective management of breast cancer depends on early diagnosis and proper monitoring
of patients' response to therapy. However, these goals are difficult to achieve because of the …

RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Insulin-like growth factor 2 (IGF2) is a 7.5 kDa mitogenic peptide hormone expressed by liver
and many other tissues. It is three times more abundant in serum than IGF1, but our …

Traditionally majority of eukaryotic gene expression is influenced by transcriptional and post-
transcriptional events. Alterations in the expression of proteins that act post-transcriptionally …

Background Excessive and inappropriate immune responses are the hallmark of several
autoimmune disorders, including the inflammatory bowel diseases (IBD): Crohn's disease …

Determination of the role of insulin-like growth factor (IGF) family components in
carcinogenesis of several human tumors is based on numerous epidemiological and pre …

Cancer stem cells (CSCs) play major roles in cancer initiation, progression, and metastasis.
It is evident from growing reports that PI3K/Akt/mTOR and Sonic Hedgehog (Shh) signaling …

The molecular mechanisms promoting lineage-specific commitment of human mesenchymal
(skeletal or stromal) stem cells (hMSCs) into adipocytes (ADs) are not fully understood …