Exercise and neuropathic pain: a general overview of preclinical and clinical research

BN Leitzelar, KF Koltyn - Sports medicine-open, 2021 - Springer
Neuropathic pain is a disease of the somatosensory system that is characterized by tingling,
burning, and/or shooting pain. Medication is often the primary treatment, but it can be costly …

Emerging relationships between exercise, sensory nerves, and neuropathic pain

MA Cooper, PM Kluding, DE Wright - Frontiers in neuroscience, 2016 - frontiersin.org
The utilization of physical activity as a therapeutic tool is rapidly growing in the medical
community and the role exercise may offer in the alleviation of painful disease states is an …

Exercise therapy normalizes BDNF upregulation and glial hyperactivity in a mouse model of neuropathic pain

C Almeida, A DeMaman, R Kusuda, F Cadetti… - Pain, 2015 - journals.lww.com
Abstract Treatment of neuropathic pain is a clinical challenge likely because of the time-
dependent changes in many neurotransmitter systems, growth factors, ionic channels …

Effect of environment on the long-term consequences of chronic pain

MC Bushnell, LK Case, M Ceko, VA Cotton, JL Gracely… - Pain, 2015 - journals.lww.com
Much evidence from pain patients and animal models shows that chronic pain does not exist
in a vacuum but has varied comorbidities and far-reaching consequences. Patients with long …

Exercise-induced hypoalgesia: potential mechanisms in animal models of neuropathic pain

K Kami, F Tajima, E Senba - Anatomical science international, 2017 - Springer
Physical exercise, such as forced treadmill running and swimming, can sufficiently improve
mechanical allodynia and heat hyperalgesia in animal models of neuropathic pain (NPP) …

[HTML][HTML] A new aspect of chronic pain as a lifestyle-related disease

E Senba, K Kami - Neurobiology of pain, 2017 - Elsevier
Physical exercise has been established as a low-cost, safe, and effective way to manage
chronic intractable pain. We investigated the underlying mechanisms of exercise-induced …

Reappraising entrapment neuropathies–mechanisms, diagnosis and management

AB Schmid, RJ Nee, MW Coppieters - Manual Therapy, 2013 - Elsevier
The diagnosis of entrapment neuropathies can be difficult because symptoms and signs
often do not follow textbook descriptions and vary significantly between patients with the …

[HTML][HTML] Histone acetylation in microglia contributes to exercise-induced hypoalgesia in neuropathic pain model mice

K Kami, S Taguchi, F Tajima, E Senba - The Journal of Pain, 2016 - Elsevier
Physical exercise can attenuate neuropathic pain (NPP), but the exact mechanism
underlying exercise-induced hypoalgesia (EIH) remains unclear. Recent studies have …

Improvements in impaired GABA and GAD65/67 production in the spinal dorsal horn contribute to exercise-induced hypoalgesia in a mouse model of neuropathic …

K Kami, S Taguchi, MS, F Tajima, E Senba - Molecular pain, 2016 - journals.sagepub.com
Background Physical exercise effectively attenuates neuropathic pain, and multiple events
including the inhibition of activated glial cells in the spinal dorsal horn, activation of the …

Neuropathic pain in taxane-induced peripheral neuropathy: evidence for exercise in treatment

E Andersen Hammond, M Pitz… - … and neural repair, 2019 - journals.sagepub.com
One in 2 Canadians is expected to acquire cancer in their lifetime. Many cancers, including
breast, ovarian, and lung cancer, are treated using taxane chemotherapy with curative …