Cell type-specific gene expression relies on transcription factors (TFs) binding DNA
sequence motifs embedded in chromatin. Understanding how motifs are accessed in …

Transcriptional regulation underlies many of the growth and developmental processes that
shape plants as well as their adaptation to their environment. Key to transcriptional control …

Biomolecular condensates are dense assemblies of proteins that form distinct biochemical
compartments without being surrounded by a membrane. Some, such as P granules and …

Short tandem repeats (STRs) are enriched in eukaryotic cis-regulatory elements and alter
gene expression, yet how they regulate transcription remains unknown. We found that STRs …

Many principles of bacterial gene regulation have been foundational to understanding
mechanisms of eukaryotic transcription. However, stark structural and functional differences …

Long non-coding RNAs (lncRNAs) outnumber protein-coding transcripts, but their functions
remain largely unknown. In this Review, we discuss the emerging roles of lncRNAs in the …

Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

Transcription is orchestrated by thousands of transcription factors (TFs) and chromatin-
associated proteins, but how these are causally connected to transcriptional activation is …

The Drosophila brain is a frequently used model in neuroscience. Single-cell transcriptome
analysis,,,,–, three-dimensional morphological classification and electron microscopy …

Most plant growth and development processes are regulated in one way or another by
auxin. The best-studied mechanism by which auxin exerts its regulatory effects is through …