FOXP3+ regulatory T cells (Treg) are indispensable for immune homoeostasis and for the
prevention of autoimmune diseases. Interleukin-2 (IL-2) signalling is critical in all aspects of …

Disease‐modifying drugs and biologics used to treat autoimmune diseases, although
promising, are non‐curative. As the field moves toward development of new approaches to …

Antigen-specific immunotherapies (ASITs) address important clinical needs in treating
autoimmune diseases. However, Type 1 diabetes is a heterogeneous disease wherein …

Abstract Type 1 diabetes (T1D) is an autoimmune disease characterized by T and B cell
responses to proteins expressed by insulin-producing pancreatic β cells, inflammatory …

Type 1 diabetes mellitus (T1DM) has been defined as an autoimmune disease
characterised by immune-mediated destruction of the pancreatic β cells, leading to absolute …

Type 1 diabetes (T1D) is a chronic autoimmune disorder in which b-cell destruction occurs
leading to the body's inability to make adequate insulin. 1, 2 According to the SEARCH …

Background Antibiotic-based plasmid selection and maintenance is a core tool in molecular
biology; however, while convenient, this strategy has numerous drawbacks for biological …

To restore immune tolerance towards self-antigens, ASIT aims to establish a favourable
balance between T effector cells and T regulatory cells. Whilst most ASITs, including …

I previously introduced a class of antibiotic-free small DNA vectors termed “Petit
Plasmids”[1]. These vectors can be maintained and replicated within engineered amino acid …

Antigen-specific immunotherapy involves the delivery of self-antigens as proteins or
peptides (or using nucleic acids encoding them) to reestablish tolerance. The Endotope …