[HTML][HTML] BRCA genes: the role in genome stability, cancer stemness and therapy resistance
I Gorodetska, I Kozeretska, A Dubrovska - Journal of Cancer, 2019 - ncbi.nlm.nih.gov
Carcinogenesis is a multistep process, and tumors frequently harbor multiple mutations
regulating genome integrity, cell division and death. The integrity of cellular genome is …
regulating genome integrity, cell division and death. The integrity of cellular genome is …
DNA double-strand breaks: signaling, repair and the cancer connection
KK Khanna, SP Jackson - Nature genetics, 2001 - nature.com
To ensure the high-fidelity transmission of genetic information, cells have evolved
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …
mechanisms to monitor genome integrity. Cells respond to DNA damage by activating a …
The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target
Targeted drugs have changed cancer treatment but are often ineffective in the long term
against solid tumours, largely because of the activation of heterogeneous oncogenic …
against solid tumours, largely because of the activation of heterogeneous oncogenic …
Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage
K Yoshida, Y Miki - Cancer science, 2004 - Wiley Online Library
BRCA1 (BReast‐CAncer susceptibility gene 1) and BRCA2 are tumor suppressor genes, the
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …
mutant phenotypes of which predispose to breast and ovarian cancers. Intensive research …
Cellular responses to DNA damage
CJ Norbury, ID Hickson - Annual review of pharmacology and …, 2001 - annualreviews.org
Cells are constantly under threat from the cytotoxic and mutagenic effects of DNA damaging
agents. These agents can either be exogenous or formed within cells. Environmental DNA …
agents. These agents can either be exogenous or formed within cells. Environmental DNA …
The prolyl isomerase PIN1: a pivotal new twist in phosphorylation signalling and disease
Protein phosphorylation regulates many cellular processes by causing changes in protein
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …
conformation. The prolyl isomerase PIN1 has been identified as a regulator of …
[HTML][HTML] Pin1 is overexpressed in breast cancer and cooperates with Ras signaling in increasing the transcriptional activity of c‐Jun towards cyclin D1
GM Wulf, A Ryo, GG Wulf, SW Lee, T Niu… - The EMBO …, 2001 - embopress.org
Phosphorylation on serines or threonines preceding proline (Ser/Thr‐Pro) is a major
signaling mechanism. The conformation of a subset of phosphorylated Ser/Thr‐Pro motifs is …
signaling mechanism. The conformation of a subset of phosphorylated Ser/Thr‐Pro motifs is …
Cancer and Alzheimer's disease inverse relationship: An age-associated diverging derailment of shared pathways
Several epidemiological studies show an inverse association between cancer and
Alzheimer's disease (AD). It is debated whether this association is the consequence of …
Alzheimer's disease (AD). It is debated whether this association is the consequence of …
Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation
SN Powell, LA Kachnic - Oncogene, 2003 - nature.com
Inheritance of one defective copy of either of the two breast cancer susceptibility genes,
BRCA1 and BRCA2, predisposes individuals to breast and ovarian cancers. Current …
BRCA1 and BRCA2, predisposes individuals to breast and ovarian cancers. Current …
BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
RI Yarden, S Pardo-Reoyo, M Sgagias, KH Cowan… - Nature …, 2002 - nature.com
The breast cancer tumor-suppressor gene, BRCA1, encodes a protein with a BRCT domain—
a motif that is found in many proteins that are implicated in DNA damage response and in …
a motif that is found in many proteins that are implicated in DNA damage response and in …