Mass spectrometry-based metabolomics: a guide for annotation, quantification and best reporting practices

S Alseekh, A Aharoni, Y Brotman, K Contrepois… - Nature …, 2021 - nature.com
Mass spectrometry-based metabolomics approaches can enable detection and
quantification of many thousands of metabolite features simultaneously. However …

Metabolomics for investigating physiological and pathophysiological processes

DS Wishart - Physiological reviews, 2019 - journals.physiology.org
Metabolomics uses advanced analytical chemistry techniques to enable the high-throughput
characterization of metabolites from cells, organs, tissues, or biofluids. The rapid growth in …

Systems biology and multi-omics integration: viewpoints from the metabolomics research community

FR Pinu, DJ Beale, AM Paten, K Kouremenos… - Metabolites, 2019 - mdpi.com
The use of multiple omics techniques (ie, genomics, transcriptomics, proteomics, and
metabolomics) is becoming increasingly popular in all facets of life science. Omics …

BioTransformer: a comprehensive computational tool for small molecule metabolism prediction and metabolite identification

Y Djoumbou-Feunang, J Fiamoncini… - Journal of …, 2019 - Springer
Background A number of computational tools for metabolism prediction have been
developed over the last 20 years to predict the structures of small molecules undergoing …

CFM-ID 3.0: significantly improved ESI-MS/MS prediction and compound identification

Y Djoumbou-Feunang, A Pon, N Karu, J Zheng, C Li… - Metabolites, 2019 - mdpi.com
Metabolite identification for untargeted metabolomics is often hampered by the lack of
experimentally collected reference spectra from tandem mass spectrometry (MS/MS). To …

Livestock metabolomics and the livestock metabolome: A systematic review

SA Goldansaz, AC Guo, T Sajed, MA Steele… - PloS one, 2017 - journals.plos.org
Metabolomics uses advanced analytical chemistry techniques to comprehensively measure
large numbers of small molecule metabolites in cells, tissues and biofluids. The ability to …

MiMeDB: the human microbial metabolome database

DS Wishart, E Oler, H Peters, AC Guo… - Nucleic Acids …, 2023 - academic.oup.com
Abstract The Human Microbial Metabolome Database (MiMeDB)(https://mimedb. org) is a
comprehensive, multi-omic, microbiome resource that connects:(i) microbes to microbial …

Systems-level annotation of a metabolomics data set reduces 25 000 features to fewer than 1000 unique metabolites

NG Mahieu, GJ Patti - Analytical chemistry, 2017 - ACS Publications
When using liquid chromatography/mass spectrometry (LC/MS) to perform untargeted
metabolomics, it is now routine to detect tens of thousands of features from biological …

Metabolomics 20 years on: what have we learned and what hurdles remain?

S Alseekh, AR Fernie - The Plant Journal, 2018 - Wiley Online Library
The term metabolome was coined in 1998, by analogy to genome, transcriptome and
proteome. The first research papers using the terms metabolomics, metabonomics …

Chemical language models enable navigation in sparsely populated chemical space

MA Skinnider, RG Stacey, DS Wishart… - Nature Machine …, 2021 - nature.com
Deep generative models are powerful tools for the exploration of chemical space, enabling
the on-demand generation of molecules with desired physical, chemical or biological …