Peptide nucleic acid (PNA) is arguably one of the most successful DNA mimics, despite a
most dramatic departure from the native structure of DNA. The present review summarizes …

Peptide nucleic acids (PNA) are deoxyribonucleic acid (DNA) mimics with a pseudopeptide
backbone. PNA is an extremely good structural mimic of DNA (or of ribonucleic acid [RNA]) …

The trans-activation response (TAR) RNA stem–loop that occurs at the 5′ end of HIV RNA
transcripts is an important antiviral target and is the site of interaction of the HIV-1 Tat protein …

Fluorescence correlation spectroscopy is a method in which fluctuations in the fluorescence
arising from a very small sample volume are correlated to obtain information about the …

Despite continuing advances in the development of macromolecules, including peptides,
proteins, and oligonucleotides, for therapeutic purposes, the successful application of these …

Since the first Handbook of Cell-Penetrating Peptides was prepared in 2001, the wealth of
new information on the use of these peptides as transport systems has in fact served to …

Towards the development of oligonucleotide analogues and siRNA as drugs, one potential
alternative to the use of liposomal transfection agents is the covalent conjugation of a cell …

Improving the delivery of synthetic oligonucleotides and their analogues into cells is an
important goal in the full development of antisense technology for control of gene expression …

Although previous efforts have focused on altering the size of drug delivery carriers with the
goal of improving the efficacy of anticancer therapy, the penetration of nuclear pores still …

Programmable site-specific nucleases promise to unlock myriad applications in basic
biology research, biotechnology and gene therapy. Gene-editing systems have …