Excessive ingestion of licorice induces a syndrome of hypokalemia and hypertension that
reflects increased activation of renal mineralocorticoid receptors by cortisol. A similar …

Publisher Summary This chapter reviews the historical perspective into the conceptual
evolution of 11β-hydroxysteroid dehydrogenase (HSD) from its pedestrian origin as an …

A syndrome is described whose features, suggestive of primary mineralocorticoid excess,
included hypertension, hypokalemia, low PRA, and responsiveness to spironolactone …

We would like to take this opportunity of expressing our sincerest thanks to the many
persons who have made adrenal tissue and related materials available to us for our work …

A role for 5α-reduction in androgen physiology was first established with the recognition that
dihydrotestosterone, the 5α-reduced metabolite of testosterone, is formed in many androgen …

A syndrome of low renin hypertension in childhood with apparent mineralocorticoid excess
associated with a defect in the peripheral metabolism of cortisol has been described …

The syndrome of apparent mineralocorticoid excess, which is not a primary disorder of the
adrenal cortex, describes the association of an unexplained hypermineralocorticoid state …

The principal side effects of the drug carbenoxolone (Biogastrone; 18β-glycyrrhetinic acid
sodium hemisuccinate) are sodium retention, hypokalemic alkalosis, suppressed plasma …

Aldosterone sensitivity is defined as an outcome variable for a given circulating level of
aldosterone. In basic and translational studies, aldosterone sensitivity has been measured …

A 4-yr-old boy with hypertension and hypokalaemic alkalosis had low plasma aldosterone
levels and renin activity. The hypertension and hypokalemia responded to spironolactone …