Developments in molecular and systems biology have enabled novel approaches to be
used in the study of inbreeding. Mechanistic and functional studies using 'omic'technologies …

Organisms rely on mutations to fuel adaptive evolution. However, many mutations impose a
negative effect on fitness. Cells may have therefore evolved mechanisms that affect the …

Myofibrillar myopathy (MFM) is a group of inherited muscular disorders characterized by
myofibril dissolution and abnormal accumulation of degradation products. The diagnosis of …

Molecular chaperones are highly conserved and ubiquitous proteins that help other proteins
in the cell to fold. Pioneering work by Rutherford and Lindquist suggested that the …

Although cancers account for over 16% of all global deaths annually, at present, no reliable
therapies exist for most types of the disease. As protein folding facilitators, heat shock …

The concept of genetic canalization has had an abiding influence on views of complex-trait
evolution. A genetically canalized system has evolved to become less sensitive to the effects …

В монографии обобщены итоги многолетних исследований в области изучения
закономерностей гомологической изменчивости морфологических структур скелета …

Intracellular organisms, such as obligate parasites and endosymbionts, typically possess
small genomes due to continuous genome decay caused by an environment with alleviated …

Better understanding how organisms respond to their abiotic environment, especially at the
biochemical level, is critical in predicting population trajectories under climate change. In …

Motivation: Molecular chaperones prevent the aggregation of their substrate proteins and
thereby ensure that they reach their functional native state. The bacterial GroEL/ES …