During adaptive immunity, B cells differentiate either into memory B cells or plasma cells and
produce antibodies against foreign antigens to fight infection. Additionally, they behave as …

Background Despite the remarkable advances made in the diagnosis and treatment of
cancer during the past couple of decades, it remains the second largest cause of mortality in …

Background Mast cells (MCs) are pleiotropic cells that accumulate in the esophagus of
patients with eosinophilic esophagitis (EoE) and are thought to contribute to disease …

Highlights•Differences in affinity, valency, concentration of FcεRI-aggregating ligands are
translated into distinct signaling outcomes.•Mast cell degranulation implicates a highly …

Inflammation is a multifactorial process and various biological mechanisms and pathways
participate in its development. The presence of inflammation is involved in pathogenesis of …

Mast cells (MC) s are evolutionarily conserved, tissue-resident immune cells with diverse
roles in allergy, cancer, and protection from infection by helminths and microorganisms. The …

Mast cells are critical effectors of allergic inflammation and protection against parasitic
infections. We previously demonstrated that transcription factors GATA2 and MITF are the …

The binding of platelet-derived growth factor D (PDGF-DD) to the NKp44 receptor activates a
distinct transcriptional program in primary IL-2 expanded human natural killer (NK) cells. We …

Mast cells (MCs) are primarily resident hematopoietic tissue cells that are localized at
external and internal surfaces of the body where they act in the first line of defense. MCs are …

Allergen-specific immunotherapy (AIT) is currently the only potential treatment for allergies
including allergic rhinitis (AR) and food allergies (FA) that can modify the underlying course …