Chromatin is partitioned on multiple length scales into subcompartments that differ from
each other with respect to their molecular composition and biological function. It is a key …

Eukaryotic cells compartmentalize their internal milieu in order to achieve specific reactions
in time and space. This organization in distinct compartments is essential to allow …

Alternative lengthening of telomeres (ALT) is a telomerase-independent telomere
maintenance mechanism that occurs in a subset of cancers. One of the hallmarks of ALT …

Small ubiquitin-like modifiers play critical roles in the DNA damage response (DDR). To
increase our understanding of SUMOylation in the mammalian DDR, we employed a …

The unlimited proliferation potential of cancer cells requires the maintenance of their
telomeres. This is frequently accomplished by reactivation of telomerase. However, in a …

The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape
senescence and apoptosis in the absence of active telomerase. A characteristic feature of …

The promyelocytic leukemia (PML) body is a phase-separated nuclear structure physically
associated with chromatin, implying its crucial roles in genome functions. However, its role in …

The maintenance of telomere length supports repetitive cell division and therefore plays a
central role in cancer development and progression. Telomeres are extended by either the …

Telomeres are nucleoprotein complexes that cap the ends of eukaryotic linear
chromosomes. Telomeric DNA is bound by shelterin protein complex to prevent telomeric …

Ring finger protein 4 (RNF4) is a SUMO-targeted ubiquitin E3 ligase with a pivotal function
in the DNA damage response (DDR). SUMO interaction motifs (SIMs) in the N-terminal part …