Redox homeostasis is an essential requirement of the biological systems for performing
various normal cellular functions including cellular growth, differentiation, senescence …

The Kelch-like ECH-associated protein 1-NF-E2-related factor 2 (KEAP1-NRF2) system
forms the major node of cellular and organismal defense against oxidative and electrophilic …

Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …

Despite the high long-term survival in localized prostate cancer, metastatic prostate cancer
remains largely incurable even after intensive multimodal therapy. The lethality of advanced …

Tight regulation of inflammation is very important to guarantee a balanced immune response
without developing chronic inflammation. One of the major mediators of the resolution of …

The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …

The Kelch-like ECH-associated protein 1 (KEAP1)/nuclear factor erythroid 2–related factor 2
(NRF2) pathway plays a physiologic protective role against xenobiotics and reactive oxygen …

Remarkable interest has risen in the idea that oxidative/nitrosative stress is mediated in the
etiology of numerous human diseases. Oxidative/Nitrosative stress is the result of an …

An unanswered question in human health is whether antioxidation prevents or promotes
cancer. Antioxidation has historically been viewed as chemopreventive, but emerging …

Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …