[HTML][HTML] Late-stage C–H functionalization offers new opportunities in drug discovery
L Guillemard, N Kaplaneris, L Ackermann… - Nature Reviews …, 2021 - nature.com
Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …
Power of biocatalysis for organic synthesis
CK Winkler, JH Schrittwieser, W Kroutil - ACS central science, 2021 - ACS Publications
Biocatalysis, using defined enzymes for organic transformations, has become a common
tool in organic synthesis, which is also frequently applied in industry. The generally high …
tool in organic synthesis, which is also frequently applied in industry. The generally high …
Late-stage functionalization
J Börgel, T Ritter - Chem, 2020 - cell.com
The term late-stage functionalization (LSF) is recent but is now frequently used in the field of
organic methodology development to describe transformations on complex molecules. Such …
organic methodology development to describe transformations on complex molecules. Such …
The crucial role of methodology development in directed evolution of selective enzymes
Directed evolution of stereo‐, regio‐, and chemoselective enzymes constitutes a unique way
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
to generate biocatalysts for synthetically interesting transformations in organic chemistry and …
Biocatalytic oxidation reactions: a chemist's perspective
JJ Dong, E Fernández‐Fueyo… - Angewandte Chemie …, 2018 - Wiley Online Library
Oxidation chemistry using enzymes is approaching maturity and practical applicability in
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …
organic synthesis. Oxidoreductases (enzymes catalysing redox reactions) enable chemists …
Recent advances in biocatalysis with chemical modification and expanded amino acid alphabet
The two main strategies for enzyme engineering, directed evolution and rational design,
have found widespread applications in improving the intrinsic activities of proteins. Although …
have found widespread applications in improving the intrinsic activities of proteins. Although …
Baeyer–Villiger monooxygenases: tunable oxidative biocatalysts
Pollution, accidents, and misinformation have earned the pharmaceutical and chemical
industry a poor public reputation, despite their undisputable importance to society …
industry a poor public reputation, despite their undisputable importance to society …
Hot spots-making directed evolution easier
Directed evolution has emerged as a powerful strategy to engineer various properties of
proteins. Traditional methods to construct libraries such as error-prone PCR and DNA …
proteins. Traditional methods to construct libraries such as error-prone PCR and DNA …
Enzyme engineering: current trends and future perspectives
Enzyme-based biocatalysts have a wide range of industrial applications for production,
processing and improving the quality attributes of animal feed, beverages, detergent, food …
processing and improving the quality attributes of animal feed, beverages, detergent, food …
[HTML][HTML] Glycosyltransferases: Mining, engineering and applications in biosynthesis of glycosylated plant natural products
B He, X Bai, Y Tan, W Xie, Y Feng, GY Yang - Synthetic and Systems …, 2022 - Elsevier
UDP-Glycosyltransferases (UGTs) catalyze the transfer of nucleotide-activated sugars to
specific acceptors, among which the GT1 family enzymes are well-known for their function in …
specific acceptors, among which the GT1 family enzymes are well-known for their function in …