Located between vessels of the choriocapillaris and light-sensitive outer segments of the
photoreceptors, the retinal pigment epithelium (RPE) closely interacts with photoreceptors in …

▪ Abstract Phototransduction is the process by which a photon of light captured by a
molecule of visual pigment generates an electrical response in a photoreceptor cell …

The functions of serotonin have been assigned through serotonin-receptor-specific drugs
and mutants,; however, because a constellation of receptors remains when a single receptor …

Inherited retinal diseases (IRD) are a leading cause of blindness in the working age
population and children. The scope of this review is to familiarise clinicians and scientists …

Regulator of G protein signaling (RGS) proteins are responsible for the rapid turnoff of G
protein–coupled receptor signaling pathways. The major mechanism whereby RGS proteins …

Gβγ subunits from heterotrimeric G proteins perform a vast array of functions in cells with
respect to signaling, often independently as well as in concert with Gα subunits. However …

When light is absorbed within the outer segment of a vertebrate photoreceptor, the
conformation of the photopigment rhodopsin is altered to produce an activated photoproduct …

The basis of the duplex theory of vision is examined in view of the dazzling array of data on
visual pigment sequences and the pigments they form, on the microspectrophotometry …

Phototransduction is the process by which light triggers an electrical signal in a
photoreceptor cell. Image-forming vision in vertebrates is mediated by two types of …

Cyclic nucleotide phosphodiesterases (PDEs) comprise a superfamily of
metallophosphohydrolases that specifically cleave the 3′, 5′-cyclic phosphate moiety of …