Variant surface antigens of Plasmodium falciparum and their roles in severe malaria
Proliferation and differentiation inside erythrocytes are important steps in the life cycle of
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
Plasmodium spp. To achieve these, the parasites export polypeptides to the surface of …
Plasmodium species: master renovators of their host cells
Plasmodium parasites, the causative agents of malaria, have developed elaborate
strategies that they use to survive and thrive within different intracellular environments …
strategies that they use to survive and thrive within different intracellular environments …
[HTML][HTML] Functional profiling of a Plasmodium genome reveals an abundance of essential genes
The genomes of malaria parasites contain many genes of unknown function. To assist drug
development through the identification of essential genes and pathways, we have measured …
development through the identification of essential genes and pathways, we have measured …
[HTML][HTML] A genome-wide CRISPR screen in Toxoplasma identifies essential apicomplexan genes
Apicomplexan parasites are leading causes of human and livestock diseases such as
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
malaria and toxoplasmosis, yet most of their genes remain uncharacterized. Here, we …
[HTML][HTML] Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
N Regev-Rudzki, DW Wilson, TG Carvalho, X Sisquella… - Cell, 2013 - cell.com
Cell-cell communication is an important mechanism for information exchange promoting cell
survival for the control of features such as population density and differentiation. We …
survival for the control of features such as population density and differentiation. We …
[HTML][HTML] Decreased K13 abundance reduces hemoglobin catabolism and proteotoxic stress, underpinning artemisinin resistance
Increased tolerance of Plasmodium falciparum to front-line artemisinin antimalarials (ARTs)
is associated with mutations in Kelch13 (K13), although the precise role of K13 remains …
is associated with mutations in Kelch13 (K13), although the precise role of K13 remains …
PTEX is an essential nexus for protein export in malaria parasites
B Elsworth, K Matthews, CQ Nie, M Kalanon… - Nature, 2014 - nature.com
During the blood stages of malaria, several hundred parasite-encoded proteins are exported
beyond the double-membrane barrier that separates the parasite from the host cell …
beyond the double-membrane barrier that separates the parasite from the host cell …
A newly discovered protein export machine in malaria parasites
Several hundred malaria parasite proteins are exported beyond an encasing vacuole and
into the cytosol of the host erythrocyte, a process that is central to the virulence and viability …
into the cytosol of the host erythrocyte, a process that is central to the virulence and viability …
[HTML][HTML] External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells
SD Kale, B Gu, DGS Capelluto, D Dou, E Feldman… - Cell, 2010 - cell.com
Pathogens of plants and animals produce effector proteins that are transferred into the
cytoplasm of host cells to suppress host defenses. One type of plant pathogens, oomycetes …
cytoplasm of host cells to suppress host defenses. One type of plant pathogens, oomycetes …
Malaria parasite proteins that remodel the host erythrocyte
Exported proteins of the malaria parasite Plasmodium falciparum interact with proteins of the
erythrocyte membrane and induce substantial changes in the morphology, physiology and …
erythrocyte membrane and induce substantial changes in the morphology, physiology and …