DJ-1 protein has multiple specific mechanisms to protect dopaminergic neurons against
neurodegeneration in Parkinson's disease. Wild type DJ-1 can acts as oxidative stress …

Parkinson's disease (PD) is caused by dopaminergic neuronal death in the substantia nigra,
resulting in a reduced level of dopamine in the striatum. Oxidative stress and mitochondrial …

Parkinson's disease (PD) is a progressive neurodegenerative movement disorder that
results primarily from the death of dopaminergic neurons in the substantia nigra. Although …

Loss-of-function DJ-1 mutations can cause early-onset Parkinson's disease. The function of
DJ-1 is unknown, but an acidic isoform accumulates after oxidative stress, leading to the …

The quest to disentangle the aetiopathogenesis of Parkinson's disease has been heavily
influenced by the genes associated with the disease. The α-synuclein-centric theory of …

Deletion and point (L166P) mutations of DJ‐1 have recently been shown to be responsible
for the onset of familial Parkinson's disease (PD, PARK7). The aim of this study was to …

Parkinson disease is a complex, multifactorial neurodegenerative disease. Although a
heritable basis was originally thought unlikely, recent studies have implicated several genes …

Mutations of the DJ-1 (PARK7) gene are linked to familial Parkinson's disease. We used
gene targeting to generate DJ-1-deficient mice that were viable, fertile, and showed no gross …

Parkinson's disease (PD) pathology is characterized by the degeneration of midbrain
dopamine neurons (DNs) ultimately leading to a progressive movement disorder in patients …

The discovery of the enzymatic formation of lactic acid from methylglyoxal dates back to
1913 and was believed to be associated with one enzyme termed ketonaldehydemutase or …