Protocadherins at the crossroad of signaling pathways
A Pancho, T Aerts, MD Mitsogiannis… - Frontiers in Molecular …, 2020 - frontiersin.org
Protocadherins (Pcdhs) are cell adhesion molecules that belong to the cadherin
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
superfamily, and are subdivided into clustered (cPcdhs) and non-clustered Pcdhs (ncPcdhs) …
Cadherins in brain morphogenesis and wiring
S Hirano, M Takeichi - Physiological reviews, 2012 - journals.physiology.org
Cadherins are Ca2+-dependent cell-cell adhesion molecules that play critical roles in
animal morphogenesis. Various cadherin-related molecules have also been identified …
animal morphogenesis. Various cadherin-related molecules have also been identified …
Protocadherins mediate dendritic self-avoidance in the mammalian nervous system
Dendritic arborizations of many neurons are patterned by a process called self-avoidance, in
which branches arising from a single neuron repel each other,,,,,,. By minimizing gaps and …
which branches arising from a single neuron repel each other,,,,,,. By minimizing gaps and …
[HTML][HTML] Chemoaffinity revisited: dscams, protocadherins, and neural circuit assembly
SL Zipursky, JR Sanes - Cell, 2010 - cell.com
The chemoaffinity hypothesis for neural circuit assembly posits that axons and their targets
bear matching molecular labels that endow neurons with unique identities and specify …
bear matching molecular labels that endow neurons with unique identities and specify …
Functional dissection of astrocyte-secreted proteins: Implications in brain health and diseases
Astrocytes, which are homeostatic cells of the central nervous system (CNS), display
remarkable heterogeneity in their morphology and function. Besides their physical and …
remarkable heterogeneity in their morphology and function. Besides their physical and …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
Combinatorial homophilic interaction between γ-protocadherin multimers greatly expands the molecular diversity of cell adhesion
D Schreiner, JA Weiner - Proceedings of the National …, 2010 - National Acad Sciences
The specificity of interactions between neurons is believed to be mediated by diverse cell
adhesion molecules, including members of the cadherin superfamily. Whereas mechanisms …
adhesion molecules, including members of the cadherin superfamily. Whereas mechanisms …
Clustered protocadherins
WV Chen, T Maniatis - Development, 2013 - journals.biologists.com
The majority of vertebrate protocadherin (Pcdh) genes are clustered in a single genomic
locus, and this remarkable genomic organization is highly conserved from teleosts to …
locus, and this remarkable genomic organization is highly conserved from teleosts to …
Injured adult motor and sensory axons regenerate into appropriate organotypic domains of neural progenitor grafts
Neural progenitor cell (NPC) transplantation has high therapeutic potential in neurological
disorders. Functional restoration may depend on the formation of reciprocal connections …
disorders. Functional restoration may depend on the formation of reciprocal connections …
The molecular basis of self-avoidance
S Lawrence Zipursky, WB Grueber - Annual review of …, 2013 - annualreviews.org
Self-avoidance, the tendency of neurites of the same cell to selectively avoid each other, is a
property of both vertebrate and invertebrate neurons. In Drosophila, self-avoidance is …
property of both vertebrate and invertebrate neurons. In Drosophila, self-avoidance is …