Abstract Purpose of Review New therapies are needed to potentiate the effects of current
immunotherapies and overcome resistance. The stimulator of interferon genes genes …

Mitochondria are master regulators of metabolism and have emerged as key signalling
organelles of the innate immune system. Each mitochondrion harbours potent agonists of …

Abstract cGAS-STING pathway, as an essential intracellular immune response pathway, has
attracted much attention in tumor immunotherapy. However, low metabolic stability of …

The DNA sensor cGAS (cyclic GMP-AMP synthase) and its adaptor protein STING
(Stimulator of Interferon Genes) detect the presence of cytosolic DNA as a sign of infection or …

Monocytes are highly plastic immune cells that modulate antitumor immunity. Therefore,
identifying factors that regulate tumor monocyte functions is critical for developing effective …

As the first line of host defense against pathogenic infections, innate immunity plays a key
role in antitumor immunotherapy. The cyclic GMP‐AMP synthase (cGAS)‐stimulator of …

The intestinal mucosa is constantly exposed to commensal microbes, opportunistic
pathogens, toxins, luminal components and other environmental stimuli. The intestinal …

The integration of functional modules at the molecular level into RNA nanostructures holds
great potential for expanding their applications. However, the quantitative integration of …

The cGAS/STING pathway provides a key host defense mechanism by detecting the
accumulation of cytoplasmic double‐stranded DNA (dsDNA) and mediating innate and …

Abstract Cyclic GMP‐AMP synthase (cGAS)–stimulator of interferon genes (STING)
signaling pathway has emerged as a key DNA‐sensing machinery in innate immunity …