Glutamate, the main excitatory amino acid in the vertebrate brain, is critically involved in
most of the physiological functions of the central nervous system. It has traditionally been …

We used lipopolysaccharide (LPS) to activate microglia that play an important role in the
brain immune system. LPS injected into the rat hippocampus CA1 region activated …

Behavioral impairments are the most empirical consequence of diabetes mellitus
documented in both humans and animal models, but the underlying causes are still poorly …

Repeated exposure of rats to the psychotomimetic drug phencyclidine (PCP) markedly
increased the response of prefrontal cortical neurons to the glutamate agonist N-methyl-d …

The Na+‐dependent glutamate/aspartate transporter GLAST plays a major role in the
removal of glutamate from the synaptic cleft. Short‐term, as well as long‐term changes in …

We have demonstrated the effects of activation of presynaptic γ-aminobutyric acid (GABA)
receptors on glutamate release using in vivo brain microdialysis. A dialysis probe inserted …

This study was undertaken to elucidate the anticonvulsive effects of zonisamide (ZNS: 25,
50, and 75 mg/kg, intraperitoneal [ip]), which was coadministered with valproic acid (VPA …

目的研究慢性应激对强迫游泳大鼠海马神经元c-fos 表达的影响. 方法采用特异性抗体的免疫
组织化学方法, 在大鼠慢性应激抑郁模型基础上, 观察急性强迫游泳应激后海马神经元c-fos …

In the present study, to clarify the role of the N-methyl-d-aspartate (NMDA) receptor in the
appearance of diazepam withdrawal signs, the changes in [3H] dizocilpine binding in …

Luminal is an anticonvulsant drug that is commonly used in the control of neonatal seizures
and epilepsy via mediating GABAergic signalling and inhibiting glutamatergic transmission …