Big data in transfusion medicine and artificial intelligence analysis for red blood cell quality control

MGM Lopes, SM Recktenwald, G Simionato… - Transfusion Medicine …, 2023 - karger.com
Background:“Artificial intelligence” and “big data” increasingly take the step from just being
interesting concepts to being relevant or even part of our lives. This general statement holds …

Structural and mechanical properties of the red blood cell's cytoplasmic membrane seen through the lens of biophysics

S Himbert, MC Rheinstädter - Frontiers in Physiology, 2022 - frontiersin.org
Red blood cells (RBCs) are the most abundant cell type in the human body and critical
suppliers of oxygen. The cells are characterized by a simple structure with no internal …

Cross-talk between red blood cells and plasma influences blood flow and omics phenotypes in severe COVID-19

SM Recktenwald, G Simionato, MGM Lopes… - Elife, 2022 - elifesciences.org
Abstract Coronavirus disease 2019 (COVID-19) is caused by the Severe Acute Respiratory
Syndrome Coronavirus 2 (SARS-CoV-2) and can affect multiple organs, among which is the …

Effect of cell age and membrane rigidity on red blood cell shape in capillary flow

M Nouaman, A Darras, T John, G Simionato, MAE Rab… - Cells, 2023 - mdpi.com
Blood flow in the microcirculatory system is crucially affected by intrinsic red blood cell
(RBC) properties, such as their deformability. In the smallest vessels of this network, RBCs …

Translatable tool to quantitatively assess the quality of red blood cell units and tailored cultured red blood cells for transfusion

L Kaestner, P Schlenke… - Proceedings of the …, 2024 - National Acad Sciences
Recently, Isiksacan et al. introduced in their perspective article the assessment of stored red
blood cells (RBCs) through lab-ona-chip (LOC) technologies for precision transfusion …

AI based image analysis of red blood cells in oscillating microchannels

A Link, IL Pardo, B Porr, T Franke - RSC advances, 2023 - pubs.rsc.org
The flow dynamics of red blood cells in vivo in blood capillaries and in vitro in microfluidic
channels is complex. Cells can obtain different shapes such as discoid, parachute, slipper …

A novel missense variant in ATP11C is associated with reduced red blood cell phosphatidylserine flippase activity and mild hereditary hemolytic anemia

MJ van Dijk, BA van Oirschot… - American journal of …, 2023 - Wiley Online Library
Abstract Adenosine Triphosphatase (ATPase) Phospholipid Transporting 11C gene
(ATP11C) encodes the major phosphatidylserine (PS) flippase in human red blood cells …

[HTML][HTML] Confinement effect on the microcapillary flow and shape of red blood cells

M Nouaman, A Darras, C Wagner, SM Recktenwald - Biomicrofluidics, 2024 - pubs.aip.org
The ability to change shape is essential for the proper functioning of red blood cells (RBCs)
within the microvasculature. The shape of RBCs significantly influences blood flow and has …

Reply to Kaestner et al.: Pioneering quantitative platforms for stored red blood cell assessment open the door for precision transfusion medicine

Z Isiksacan, A D'Alessandro… - Proceedings of the …, 2024 - National Acad Sciences
In a recent Perspective, we emphasized the lack of translatable tools to objectively assess
the quality of stored red blood cells (RBC) for “real age” determination of stored units and …

Artificial intelligence: training the trainer

L Kaestner - British Journal of Haematology, 2022 - Wiley Online Library
Including artificial intelligence in haematological education is compulsory but should not be
limited to students. Experienced haematologist and decision‐makers in the clinical …