Selenium (Se) is a nutritional trace mineral essential for various aspects of human health
that exerts its effects mainly through its incorporation into selenoproteins as the amino acid …

Genetic decoding is not 'frozen'as was earlier thought, but dynamic. One facet of this is
frameshifting that often results in synthesis of a C-terminal region encoded by a new frame …

Stop codon readthrough is used extensively by viruses to expand their gene expression.
Until recent discoveries in Drosophila, only a very limited number of readthrough cases in …

Nonsense-mediated decay is well known by the lucid definition of being a RNA surveillance
mechanism that ensures the speedy degradation of mRNAs containing premature …

Translation initiation is the major regulatory step defining the rate of protein production from
an mRNA. Meanwhile, the impact of nonuniform ribosomal elongation rates is largely …

The expression of selenoproteins is controlled on each one of the textbook steps of protein
biosynthesis, ie, during gene transcription, RNA processing, translation and …

Abstract In Sindbis, Venezuelan equine encephalitis and related alphaviruses, the
polymerase is translated as a fusion with other non-structural proteins via readthrough of a …

Significance: Selenium is an essential trace element that is incorporated in the small but vital
family of proteins, namely the selenoproteins, as the selenocysteine amino acid residue. In …

BACKGROUND: The amino acid selenocysteine (Sec) is the major biological form of the
trace element selenium. Sec is co-translationally incorporated in selenoproteins. There are …

Incorporation of selenium into∼ 25 mammalian selenoproteins occurs by translational
recoding whereby in-frame UGA codons are redefined to encode the selenium containing …