The mucus clearance system is the dominant mechanical host defense system of the human
lung. Mucus is cleared from the lung by cilia and airflow, including both two-phase gas-liquid …

Inflammation is a biological response of the immune system that can be triggered by a
variety of factors, including pathogens, damaged cells and toxic compounds. These factors …

Increasing evidence suggests that the lung microbiome plays an important role in chronic
obstructive pulmonary disease (COPD) severity. However, the dynamics of the lung …

Chronic obstructive pulmonary disease (COPD) involves chronic inflammation of the lung,
particularly in peripheral airways and parenchyma, which increases during acute …

We welcome the report by the SPIROMICS investigators in The Lancet Respiratory
Medicine, 1 repeating our 2010 ECLIPSE analysis2 describing exacerbations in chronic …

Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) are
heterogeneous with respect to inflammation and etiology. Objectives: Investigate biomarker …

Chronic bronchitis (CB) is a common but variable phenomenon in chronic obstructive
pulmonary disease (COPD). It has numerous clinical consequences, including an …

Increasing evidence indicates that chronic obstructive pulmonary disease (COPD) is a
complex disease involving more than airflow obstruction. Airflow obstruction has profound …

Rationale: Exacerbations of chronic obstructive pulmonary disease (COPD) and responses
to treatment are heterogeneous. Objectives: Investigate the usefulness of blood eosinophils …

Macrolides have diverse biological activities and an ability to modulate inflammation and
immunity in eukaryotes without affecting homeostatic immunity. These properties have led to …