Gastric cancer is a deadly disease and remains the third leading cause of cancer-related
death worldwide. The 5-year overall survival rate of patients with early-stage localized …

RHO GTPases are a subfamily of the RAS superfamily of proteins, which are highly
conserved in eukaryotic species and have important biological functions, including actin …

Branched-chain amino acid (BCAA) metabolism is potentially linked with development of
pancreatic ductal adenocarcinoma (PDAC),,-. BCAA transaminase 2 (BCAT2) was essential …

Background An increasing number of studies have shown that long noncoding RNAs
(lncRNAs) play essential roles in tumor initiation and progression. LncRNAs act as tumor …

The cell cycle, over which cells grow and divide, is a fundamental process of life. Its
dysregulation has devastating consequences, including cancer,–. The cell cycle is driven by …

Rationale: Resistance to androgen-deprivation therapy (ADT) associated with metastatic
progression remains a challenging clinical task in prostate cancer (PCa) treatment. Current …

PLAGL2 is upregulated in various tumors, including bladder cancer (BCa). However, the
mechanisms underlying the tumorigenic effects of PLAGL2 in BCa remain unclear. In our …

The estrous cycle is regulated by rhythmic endocrine interactions of the nervous and
reproductive systems, which coordinate the hormonal and ovulatory functions of the ovary …

Background Osteosarcoma (OS) is a malignant tumor mainly occurring in young people.
Due to the limited effective therapeutic strategies, OS patients cannot achieve further …

Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and
progression of nasopharyngeal carcinoma (NPC), which have not been thoroughly …