[HTML][HTML] Arketamine, a new rapid-acting antidepressant: a historical review and future directions
J Zhang, W Yao, K Hashimoto - Neuropharmacology, 2022 - Elsevier
The N-methyl-d-aspartate receptor (NMDAR) antagonist (R, S)-ketamine causes rapid onset
and sustained antidepressant actions in treatment-resistant patients with major depressive …
and sustained antidepressant actions in treatment-resistant patients with major depressive …
Role of phosphodiesterases in the pathophysiology of neurodevelopmental disorders
Phosphodiesterases (PDEs) are enzymes involved in the homeostasis of both cAMP and
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …
cGMP. They are members of a family of proteins that includes 11 subfamilies with different …
Transient stimulation with psychoplastogens is sufficient to initiate neuronal growth
C Ly, AC Greb, MV Vargas, WC Duim… - ACS Pharmacology & …, 2020 - ACS Publications
Cortical neuron atrophy is a hallmark of depression and includes neurite retraction, dendritic
spine loss, and decreased synaptic density. Psychoplastogens, small molecules capable of …
spine loss, and decreased synaptic density. Psychoplastogens, small molecules capable of …
[HTML][HTML] Microglia and BDNF at the crossroads of stressor related disorders: Towards a unique trophic phenotype
Stressors ranging from psychogenic/social to neurogenic/injury to systemic/microbial can
impact microglial inflammatory processes, but less is known regarding their effects on …
impact microglial inflammatory processes, but less is known regarding their effects on …
The molecular effects of environmental enrichment on Alzheimer's disease
Environmental enrichment (EE) is an environmental paradigm encompassing sensory,
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …
cognitive, and physical stimulation at a heightened level. Previous studies have reported the …
BDNF as a mediator of antidepressant response: recent advances and lifestyle interactions
S Cubillos, O Engmann, A Brancato - International journal of molecular …, 2022 - mdpi.com
Conventional antidepressants are widely employed in several psychiatric and neurologic
disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are …
disorders, yet the mechanisms underlying their delayed and partial therapeutic effects are …
Revisiting the expression of BDNF and its receptors in mammalian development
EE Esvald, J Tuvikene, CS Kiir, A Avarlaid… - Frontiers in Molecular …, 2023 - frontiersin.org
Brain-derived neurotrophic factor (BDNF) promotes the survival and functioning of neurons
in the central nervous system and contributes to proper functioning of many non-neural …
in the central nervous system and contributes to proper functioning of many non-neural …
The multiple roles of salt-inducible kinases in regulating physiology
A Jagannath, L Taylor, Y Ru, Z Wakaf… - Physiological …, 2023 - journals.physiology.org
Salt-inducible kinases (SIKs), which comprise a family of three homologous serine-threonine
kinases, were first described for their role in sodium sensing but have since been shown to …
kinases, were first described for their role in sodium sensing but have since been shown to …
Human umbilical cord-derived mesenchymal stem cells ameliorate perioperative neurocognitive disorder by inhibiting inflammatory responses and activating BDNF …
P Wei, M Jia, X Kong, W Lyu, H Feng, X Sun… - Stem Cell Research & …, 2023 - Springer
Background Perioperative neurocognitive disorder (PND) is a key complication affecting
older individuals after anesthesia and surgery. Failure to translate multiple pharmacological …
older individuals after anesthesia and surgery. Failure to translate multiple pharmacological …
Naringenin and apigenin ameliorates corticosterone-induced depressive behaviors
L Zhang, RR Lu, RH Xu, HH Wang, WS Feng… - Heliyon, 2023 - cell.com
Background Depression is a common kind of mental illness, and it becomes the main health
burden in the world. Purpose The aim of this study was to investigate the antidepressant …
burden in the world. Purpose The aim of this study was to investigate the antidepressant …