Extracellular protein components of amyloid plaques and their roles in Alzheimer's disease pathology
Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …
Metabolic dysregulation contributes to the progression of Alzheimer's disease
X Yan, Y Hu, B Wang, S Wang, X Zhang - Frontiers in neuroscience, 2020 - frontiersin.org
Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …
Glycolytic metabolism, brain resilience, and Alzheimer's disease
X Zhang, N Alshakhshir, L Zhao - Frontiers in Neuroscience, 2021 - frontiersin.org
Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …
A meta-analysis of Alzheimer's disease brain transcriptomic data
H Patel, RJB Dobson… - Journal of Alzheimer's …, 2019 - content.iospress.com
Background: Microarray technologies have identified imbalances in the expression of
specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there …
specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there …
The triangle of death in Alzheimer's disease brain: the aberrant cross-talk among energy metabolism, mammalian target of rapamycin signaling, and protein …
Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …
represents one of the most disabling conditions. AD shares many features in common with …
Neurodegeneration and Alzheimer's disease (AD). What can proteomics tell us about the Alzheimer's brain?
G Moya-Alvarado, N Gershoni-Emek, E Perlson… - Molecular & Cellular …, 2016 - ASBMB
Neurodegenerative diseases, such as Alzheimer′ s diseases (AD), are becoming more
prevalent as the population ages. However, the mechanisms that lead to synapse …
prevalent as the population ages. However, the mechanisms that lead to synapse …
[HTML][HTML] Linking mitochondrial dysfunction, metabolic syndrome and stress signaling in Neurodegeneration
SK Jha, NK Jha, D Kumar, RK Ambasta… - Biochimica et Biophysica …, 2017 - Elsevier
Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes,
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …
Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process
G Cenini, C Rüb, M Bruderek… - Molecular biology of the …, 2016 - Am Soc Cell Biol
Aβ peptides play a central role in the etiology of Alzheimer disease (AD) by exerting cellular
toxicity correlated with aggregate formation. Experimental evidence has shown …
toxicity correlated with aggregate formation. Experimental evidence has shown …
The writers, readers, and erasers in redox regulation of GAPDH
MA Tossounian, B Zhang, I Gout - Antioxidants, 2020 - mdpi.com
Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …