Alzheimer's disease (AD) is pathologically defined by the presence of fibrillar amyloid β (Aβ)
peptide in extracellular senile plaques and tau filaments in intracellular neurofibrillary …

Alzheimer's disease (AD) is an incurable neurodegenerative disease. Numerous studies
have demonstrated a critical role for dysregulated glucose metabolism in its pathogenesis …

The single gene, single protein, single function hypothesis is increasingly becoming
obsolete. Numerous studies have demonstrated that individual proteins can moonlight …

Alzheimer's disease (AD) is the most common form of age-related dementia. Despite
decades of research, the etiology and pathogenesis of AD are not well understood. Brain …

Background: Microarray technologies have identified imbalances in the expression of
specific genes and biological pathways in Alzheimer's disease (AD) brains. However, there …

Significance: Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder and
represents one of the most disabling conditions. AD shares many features in common with …

Neurodegenerative diseases, such as Alzheimer′ s diseases (AD), are becoming more
prevalent as the population ages. However, the mechanisms that lead to synapse …

Mounting evidence suggests a link between metabolic syndrome (MetS) such as diabetes,
obesity, non-alcoholic fatty liver disease in the progression of Alzheimer's disease (AD) …

Aβ peptides play a central role in the etiology of Alzheimer disease (AD) by exerting cellular
toxicity correlated with aggregate formation. Experimental evidence has shown …

Glyceraldehyde 3–phosphate dehydrogenase (GAPDH) is a key glycolytic enzyme, which is
crucial for the breakdown of glucose to provide cellular energy. Over the past decade …