A wide body of evidence suggests that voltage-gated sodium channels (VGSCs) are
expressed de novo in several human carcinomas where channel activity promotes a variety …

Local anesthetics are widely used during clinical cancer surgeries. Studies have suggested
that the use and the type of anesthesia affect cancer outcomes. In vivo studies and clinical …

Cancer is a major global health problem and the second leading cause of death worldwide.
When detected early, surgery provides a potentially curative intervention for many solid …

Cancer is a leading contributor to deaths worldwide. Surgery is the primary treatment for
resectable cancers. Nonetheless, it also results in inflammatory response, angiogenesis …

The question of whether anesthetic, analgesic or other perioperative intervention during
cancer resection surgery might influence long-term oncologic outcomes has generated …

While cancer treatment has improved dramatically, it has also encountered many critical
challenges, such as disease recurrence, metastasis, and drug resistance, making new drugs …

Breast cancer recurs in 20% of patients following intended curative resection. In vitro data
indicates that amide local anaesthetics, including lidocaine, inhibit cancer cell metastasis by …

Objectives Antiepileptic and antiarrhythmic drugs inhibit voltage-gated sodium (Na+)
channels (VGSCs), and preclinical studies show that these medications reduce tumour …

Local anesthetics are frequently employed during surgery in order to control peri-and
postoperative pain. Retrospective studies have revealed an unexpected correlation between …

The use of anesthetics in the surgical resection of tumors may influence the prognosis of
cancer patients. Lidocaine, a local anesthetic, is known to act as a chemosensitizer and …