Therapies with genetically modified T cells that express chimeric antigen receptors (CARs)
specific for CD19 or B cell maturation antigen (BCMA) are approved to treat certain B cell …

Antibodies are essential components of an adaptive immune response. Immunoglobulin G
(IgG) is the most common type of antibody found in circulation and extracellular fluids …

Abstract Coronavirus disease 2019 (COVID-19) can damage cerebral small vessels and
cause neurological symptoms. Here we describe structural changes in cerebral small …

Obtaining efficient drug delivery to the brain remains the biggest challenge for the
development of therapeutics to treat diseases of the central nervous system. The main …

Brain exposure of systemically administered biotherapeutics is highly restricted by the blood-
brain barrier (BBB). Here, we report the engineering and characterization of a BBB transport …

Several lines of evidence suggest that stress induces the neurovascular dysfunction
associated with increased blood–brain barrier (BBB) permeability, which could be an …

Brain glioma treatment with checkpoint inhibitor antibodies to cytotoxic T-lymphocyte-
associated antigen 4 (a-CTLA-4) and programmed cell death-1 (a-PD-1) was largely …

Background Receptor-mediated transcytosis is one of the major routes for drug delivery of
large molecules into the brain. The aim of this study was to develop a novel model of the …

The homeostasis of the central nervous system (CNS) is ensured by the endothelial,
epithelial, mesothelial and glial brain barriers, which strictly control the passage of …

The blood–brain barrier is a dynamic multicellular interface that regulates the transport of
molecules between the blood circulation and the brain parenchyma. Proteins and peptides …