TRP (transient receptor potential) ion channel family: Structures, biological functions and therapeutic interventions for diseases

M Zhang, Y Ma, X Ye, N Zhang, L Pan… - Signal Transduction and …, 2023 - nature.com
Transient receptor potential (TRP) channels are sensors for a variety of cellular and
environmental signals. Mammals express a total of 28 different TRP channel proteins, which …

New and evolving treatments for neurologic dysphagia

A Sasegbon, I Cheng, B Labeit, S Lapa, N Rommel… - Drugs, 2024 - Springer
Despite swallowing being a frequently performed daily function, it is highly complex. For a
safe swallow to occur, muscles within the head, neck, and thorax need to contract in a …

[HTML][HTML] Effect of capsaicinoids on neurophysiological, biochemical, and mechanical parameters of swallowing function

S Suntrup-Krueger, P Muhle, I Kampe, P Egidi, T Ruck… - …, 2021 - Elsevier
Oropharyngeal dysphagia is prevalent in age-related neurological disorders presenting with
impaired efficacy and safety of swallowing due to a loss of muscle force and sensory deficits …

Modulation of pharyngeal swallowing by bolus volume and viscosity

L Ferris, S Doeltgen, C Cock… - American Journal …, 2021 - journals.physiology.org
Oropharyngeal swallowing involves complex neuromodulation to accommodate changing
bolus characteristics. The pressure events during deglutitive pharyngeal reconfiguration and …

Oropharyngeal dysphagia in older people is associated with reduced pharyngeal sensitivity and low substance P and CGRP concentration in saliva

N Tomsen, O Ortega, W Nascimento, S Carrión… - Dysphagia, 2022 - Springer
Abstract Substance P (SP) and Calcitonine gene-related peptide (CGRP) are released by
sensory nerve fibers in the oropharynx. Patients with oropharyngeal dysphagia (OD) present …

Functional dynamics and allosteric modulation of TRPA1

H Koldsø, MØ Jensen, V Jogini, DE Shaw - Structure, 2023 - cell.com
The cation channel TRPA1 is a potentially important drug target, and characterization of
TRPA1 functional dynamics might help guide structure-based drug design. Here, we present …

Brain and pharyngeal responses associated with pharmacological treatments for oropharyngeal dysphagia in older patients

P Clavé, O Ortega, L Rofes, D Alvarez-Berdugo… - Dysphagia, 2023 - Springer
Impaired pharyngo-laryngeal sensory function is a critical mechanism for oropharyngeal
dysphagia (OD). Discovery of the TRP family in sensory nerves opens a window for new …

[HTML][HTML] Transient receptor potential channels as an emerging therapeutic target for oropharyngeal dysphagia

MZ Hossain, J Kitagawa - Japanese Dental Science Review, 2023 - Elsevier
Oropharyngeal dysphagia is a serious health concern in older adults and patients with
neurological disorders. Current oropharyngeal dysphagia management largely relies on …

Targeting chemosensory ion channels in peripheral swallowing-related regions for the management of oropharyngeal dysphagia

MZ Hossain, H Ando, S Unno, J Kitagawa - International Journal of …, 2020 - mdpi.com
Oropharyngeal dysphagia, or difficulty in swallowing, is a major health problem that can lead
to serious complications, such as pulmonary aspiration, malnutrition, dehydration, and …

A comparative study on the effect of acute pharyngeal stimulation with TRP agonists on the biomechanics and neurophysiology of swallow response in patients with …

N Tomsen, O Ortega, D Alvarez-Berdugo… - International Journal of …, 2022 - mdpi.com
Fluid thickening is the main compensatory strategy for patients with oropharyngeal
dysphagia (OD) associated with aging or neurological diseases, and there is still no …