Stimulation strategies for improving the resolution of retinal prostheses
Electrical stimulation using implantable devices with arrays of stimulating electrodes is an
emerging therapy for neurological diseases. The performance of these devices depends …
emerging therapy for neurological diseases. The performance of these devices depends …
Honeycomb-shaped electro-neural interface enables cellular-scale pixels in subretinal prosthesis
High-resolution visual prostheses require small, densely packed pixels, but limited
penetration depth of the electric field formed by a planar electrode array constrains such …
penetration depth of the electric field formed by a planar electrode array constrains such …
Optimization of pillar electrodes in subretinal prosthesis for enhanced proximity to target neurons
Objective. High-resolution prosthetic vision requires dense stimulating arrays with small
electrodes. However, such miniaturization reduces electrode capacitance and penetration of …
electrodes. However, such miniaturization reduces electrode capacitance and penetration of …
An extraocular electrical stimulation approach to slow down the progression of retinal degeneration in an animal model
Retinal diseases such as retinitis pigmentosa (RP) and age-related macular degeneration
(AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has …
(AMD) are characterized by unrelenting neuronal death. However, electrical stimulation has …
The relationship between morphological properties and thresholds to extracellular electric stimulation in α RGCs
Objective. Retinal prostheses strive to restore vison to patients that are blind from retinal
degeneration by electrically stimulating surviving retinal ganglion cells (RGCs). The quality …
degeneration by electrically stimulating surviving retinal ganglion cells (RGCs). The quality …
Closed-loop efficient searching of optimal electrical stimulation parameters for preferential excitation of retinal ganglion cells
The ability for visual prostheses to preferentially activate functionally-distinct retinal ganglion
cells (RGCs) is important for improving visual perception. This study investigates the use of …
cells (RGCs) is important for improving visual perception. This study investigates the use of …
Electrode-size dependent thresholds in subretinal neuroprosthetic stimulation
Objective. Retinal prostheses have shown promising results in restoring some visual
perception to blind patients but successful identification of objects of different size remains a …
perception to blind patients but successful identification of objects of different size remains a …
On optimal coupling of the 'electronic photoreceptors' into the degenerate retina
Objective To restore sight in atrophic age-related macular degeneration, the lost
photoreceptors can be replaced with electronic implants, which replicate their two major …
photoreceptors can be replaced with electronic implants, which replicate their two major …
High-amplitude electrical stimulation can reduce elicited neuronal activity in visual prosthesis
Retinal electrostimulation is promising a successful therapy to restore functional vision.
However, a narrow stimulating current range exists between retinal neuron excitation and …
However, a narrow stimulating current range exists between retinal neuron excitation and …
Optimal electric stimulus amplitude improves the selectivity between responses of ON versus OFF types of retinal ganglion cells
Outer retinal degenerative diseases destroy photoreceptors primarily in the retina, resulting
in a profound vision loss. Fortunately, surviving retinal neurons can be electrically stimulated …
in a profound vision loss. Fortunately, surviving retinal neurons can be electrically stimulated …