Fluorescent calcium indicators are a popular means for observing the spiking activity of
large neuronal populations, but extracting the activity of each neuron from raw fluorescence …

Sensory perception depends on the context in which a stimulus occurs. Prevailing models
emphasize cortical feedback as the source of contextual modulation. However, higher order …

The interactions between neocortical areas are fluid and state-dependent, but how
individual neurons couple to cortex-wide network dynamics remains poorly understood. We …

Sensory processing involves information flow between neocortical areas, assumed to rely
on direct intracortical projections. However, cortical areas may also communicate indirectly …

Calcium imaging data promises to transform the field of neuroscience by making it possible
to record from large populations of neurons simultaneously. However, determining the exact …

Calcium imaging has led to discoveries about neural correlates of behavior in subcortical
neurons, including dopamine (DA) neurons. However, spike inference methods have not …

Despite decades of microelectrode recordings, fundamental questions remain about how
auditory cortex represents sound-source location. Here, we used in vivo 2-photon calcium …

Two-photon calcium imaging of neuronal responses is an increasingly accessible
technology for probing population responses in cortex at single cell resolution, and with …

Calcium imaging is becoming an increasingly popular technology to indirectly measure
activity patterns in local neuronal networks. Based on the dependence of calcium …

Objective: Although optical imaging of neurons using fluorescent genetically encoded
calcium sensors has enabled large-scale in vivo experiments, the sensors' slow dynamics …