The α-and β-globin gene families of jawed vertebrates have diversified with respect to both
gene function and the developmental timing of gene expression. Phylogenetic …

The apparent stasis in the evolution of avian chromosomes suggests that birds may have
experienced relatively low rates of gene gain and loss in multigene families. To investigate …

The genes that encode the α-and β-chain subunits of vertebrate hemoglobin have served as
a model system for elucidating general principles of gene family evolution, but little is known …

Gene duplication is thought to play an important role in the co-option of existing protein
functions to new physiological pathways. The globin superfamily of genes provides an …

Phylogenetic relationships among reptiles were examined using previously published and
newly determined hemoglobin sequences. Trees reconstructed from these sequences using …

Tetrapod vertebrates possess multiple α-and β-like globin genes that are ontogenetically
regulated, such that functionally distinct hemoglobin (Hb) isoforms are synthesized during …

The chicken (Gallus gallus) is one of the primary models for embryological and
developmental studies. In order to begin to understand the molecular mechanisms …

Tetrameric hemoglobins (Hbs) A and D were isolated from red blood cells of the Aldabra
giant tortoises, Geochelone gigantea, by a hydrophobic interaction chromatography. After …

Extensive measurements of oxygen binding by some vertebrate hemoglobins (Hbs) have
suggested an unusually high degree of cooperativity with reported Hill coefficients, nH …

The data on the structure of gene domains of both mammalian and avian α-and β-globin
genes are reviewed. The specific features of chromatin, DNA binding to the nuclear matrix …