There is a large unmet medical need to develop disease-modifying treatment options for
individuals with age-related degenerative diseases of the central nervous system. The …

Alzheimer's disease (AD) is a neurodegenerative disease that is characterized by
progressive memory decline and cognitive dysfunctions. Although the causes of AD have …

In the injured adult central nervous system (CNS), activation of pro-growth molecular
pathways in neurons leads to long-distance regeneration. However, most regenerative …

Inhibitory control deficits are prevalent in multiple neuropsychiatric conditions. The
communication-as well as the connectivity-between corticolimbic regions of the brain are …

Synaptic connectivity within adult circuits exhibits a remarkable degree of cellular and
subcellular specificity. We report that the axon guidance receptor Robo2 plays a role in …

Schizophrenia (SZ) is a complex neuropsychiatric disorder, affecting 1% of the world
population. Long-standing clinical observations and molecular data have pointed to a …

Despite the identification of Aβ plaques and NFTs as biomarkers for Alzheimer's disease
(AD) pathology, therapeutic interventions remain elusive, with neither an absolute …

Neurons migrate from their birthplaces to the destinations, and extending axons navigate to
their synaptic targets by sensing various extracellular cues in spatiotemporally controlled …

The extracellular matrix (ECM) is a dynamic and complex network of proteins and molecules
that surrounds cells and tissues in the nervous system and orchestrates a myriad of …

Neurocognitive consequences of blast-induced traumatic brain injury (bTBI) pose significant
concerns for military service members and veterans with the majority of “invisible injury.” …