PARP inhibitors as single agents and in combination therapy: the most promising treatment strategies in clinical trials for BRCA-mutant ovarian and triple-negative …
L Luo, K Keyomarsi - Expert opinion on investigational drugs, 2022 - Taylor & Francis
Introduction Poly (ADP-ribose) polymerase inhibitors (PARPis) are an exciting class of
agents that have shown efficacy, particularly for BRCA-mutant triple-negative breast cancer …
agents that have shown efficacy, particularly for BRCA-mutant triple-negative breast cancer …
Tryptophan metabolism and disposition in cancer biology and immunotherapy
AAB Badawy - Bioscience Reports, 2022 - portlandpress.com
Tumours utilise tryptophan (Trp) and its metabolites to promote their growth and evade host
defences. They recruit Trp through up-regulation of Trp transporters, and up-regulate key …
defences. They recruit Trp through up-regulation of Trp transporters, and up-regulate key …
A double-edged sword: the two faces of PARylation
M Kang, S Park, SH Park, HG Lee, JH Park - International journal of …, 2022 - mdpi.com
Poly ADP-ribosylation (PARylation) is a post-translational modification process. Following
the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the …
the discovery of PARP-1, numerous studies have demonstrated the role of PARylation in the …
DNA Methylation signature of aging: Potential impact on the pathogenesis of parkinson's disease
Regulation of gene expression by epigenetic modifications means lasting and heritable
changes in the function of genes without alterations in the DNA sequence. Of all epigenetic …
changes in the function of genes without alterations in the DNA sequence. Of all epigenetic …
Epidrugs in the therapy of central nervous system disorders: a way to drive on?
MG Gladkova, E Leidmaa, EA Anderzhanova - Cells, 2023 - mdpi.com
The polygenic nature of neurological and psychiatric syndromes and the significant impact
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …
of environmental factors on the underlying developmental, homeostatic, and neuroplastic …
DNA methylation and histone variants in aging and cancer
A Mangelinck, C Mann - International Review of Cell and Molecular Biology, 2021 - Elsevier
Aging-related diseases such as cancer can be traced to the accumulation of molecular
disorder including increased DNA mutations and epigenetic drift. We provide a …
disorder including increased DNA mutations and epigenetic drift. We provide a …
Pleiotropic role of PARP1: An overview
Abstract Poly (ADP-ribose) polymerase 1 (PARP1) protein is encoded by the PARP1 gene
located on chromosome 1 (1q42. 12) in human cells. It plays a crucial role in post …
located on chromosome 1 (1q42. 12) in human cells. It plays a crucial role in post …
The role of epigenetic changes in the pathology and treatment of inherited retinal diseases
AL Miller, RE James, AR Harvey… - Frontiers in Cell and …, 2023 - frontiersin.org
Elucidation of the cellular changes that occur in degenerating photoreceptors of people with
inherited retinal diseases (IRDs) has been a focus for many research teams, leading to …
inherited retinal diseases (IRDs) has been a focus for many research teams, leading to …
DNA methylation malleability and dysregulation in cancer progression: Understanding the role of PARP1
R Srivastava, N Lodhi - Biomolecules, 2022 - mdpi.com
Mammalian genomic DNA methylation represents a key epigenetic modification and its
dynamic regulation that fine-tunes the gene expression of multiple pathways during …
dynamic regulation that fine-tunes the gene expression of multiple pathways during …
PAR recognition by PARP1 regulates DNA‐dependent activities and independently stimulates catalytic activity of PARP1
Poly (ADP‐ribosyl) ation is predominantly catalyzed by Poly (ADP‐ribose) polymerase 1
(PARP1) in response to DNA damage, mediating the DNA repair process to maintain …
(PARP1) in response to DNA damage, mediating the DNA repair process to maintain …