The collaborative study on the genetics of alcoholism (COGA) is a multi‐site,
multidisciplinary project with the goal of identifying how genes are involved in alcohol use …

Abstract Alcohol Use Disorder is a complex genetic disorder, involving genetic, neural, and
environmental factors, and their interactions. The Collaborative Study on the Genetics of …

Lifetime and temporal co-occurrence of substance use disorders (SUDs) is common and
compared with individual SUDs is characterized by greater severity, additional psychiatric …

Introduction Early mid-life is marked by accumulating risks for cardiometabolic illness linked
to health-risk behaviors like nicotine use. Identifying polygenic indices (PGI) has enriched …

Alcohol use disorders (AUD) are complex traits that are moderately heritable. A variety of
approaches have been developed that allow researchers to better understand their genetic …

Importance Many psychiatric outcomes share a common etiologic pathway reflecting
behavioral disinhibition, generally referred to as externalizing (EXT) disorders. Recent …

Opioids are an effective analgesic for acute and chronic pain, but also carry a considerable
risk of addiction leading to millions of opioid use disorder (OUD) cases and tens of …

Although genome-wide association studies (GWAS) have identified loci associated with
alcohol consumption and alcohol use disorder (AUD), they do not identify which variants are …

We briefly review our recently published approach to mining digenic genotype patterns,
which consist of two genotypes each originating in a different DNA variant. We do this for a …

The target of alcohol's effect on the central nervous system has been sought for more than
50 years in the brain's GABA system. The behavioral and emotional effects of alcohol in …