Congenital heart disease is a major cause of morbidity and mortality throughout life.
Mutations in numerous transcription factors have been identified in patients and families with …

The multi-chambered mammalian heart arises from a simple tube by polar elongation,
myocardial differentiation and morphogenesis. Members of the large family of T-box (Tbx) …

Although all human tissues carry out common processes, tissues are distinguished by gene
expression patterns, implying that distinct regulatory programs control tissue specificity. In …

Left ventricular non-compaction (LVNC) is the third most prevalent cardiomyopathy in
children and its pathogenesis has been associated with the developmental defect of the …

Congenital heart disease (CHD) affects nearly 1% of the population. It is a complex disease,
which may be caused by multiple genetic and environmental factors. Studies in human …

Human mutations in or variants of TBX20 are associated with congenital heart disease,
cardiomyopathy, and arrhythmias. To investigate whether cardiac disease in patients with …

Background Ostium secundum atrial septal defects (ASDII) account for approximately 10%
of all congenital heart defects (CHD), and mutations in cardiac transcription factors …

Perturbations in cardiac development result in congenital heart disease, the leading cause
of birth defect–related infant morbidity and mortality. Advances in cardiac developmental …

Tbx20 is a member of the Tbx1 subfamily of T-box-containing genes and is known to play a
variety of fundamental roles in cardiovascular development and homeostasis as well as …

Several studies have demonstrated that hematopoietic cells originate from endothelium in
early development; however, the phenotypic progression of progenitor cells during human …