The degree of frailty as a translational measure of health in aging

SE Howlett, AD Rutenberg, K Rockwood - Nature Aging, 2021 - nature.com
Frailty is a multiply determined, age-related state of increased risk for adverse health
outcomes. We review how the degree of frailty conditions the development of late-life …

Frailty-aware care: giving value to frailty assessment across different healthcare settings

KF Boreskie, JL Hay, PE Boreskie, RC Arora… - BMC geriatrics, 2022 - Springer
Healthcare systems need to adapt to better serve an aging population with complex
presentations. Frailty assessments are a potential means to address this heterogeneity in …

Screening for and managing the person with frailty in primary care: ICFSR consensus guidelines

JG Ruiz, E Dent, JE Morley, RA Merchant… - The journal of nutrition …, 2020 - Springer
1. Geriatric Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA; 2.
Torrens University of Australia, Adelaide and Baker Heart and Diabetes Institute, Melbourne …

Changes in the severity and lethality of age-related health deficit accumulation in the USA between 1999 and 2018: a population-based cohort study

JM Blodgett, K Rockwood, O Theou - The Lancet Healthy Longevity, 2021 - thelancet.com
Background With an ageing population, the number of people with frailty is increasing.
Despite this trend, the extent to which the severity and lethality of frailty have changed over …

Epigenetic age is associated with baseline and 3-year change in frailty in the Canadian Longitudinal Study on Aging

CP Verschoor, DTS Lin, MS Kobor, O Mian, J Ma… - Clinical …, 2021 - Springer
Background The trajectory of frailty in older adults is important to public health; therefore,
markers that may help predict this and other important outcomes could be beneficial …

How to construct a frailty index from an existing dataset in 10 steps

O Theou, C Haviva, L Wallace, SD Searle… - Age and …, 2023 - academic.oup.com
Background The frailty index is commonly used in research and clinical practice to quantify
health. Using a health deficit accumulation model, a frailty index can be calculated …

Frailty assessment for COVID-19 follow-up: a prospective cohort study

I Müller, M Mancinetti, A Renner… - BMJ open …, 2022 - bmjopenrespres.bmj.com
Background The Clinical Frailty Scale (CFS) is increasingly used for clinical decision making
in acute care but little is known about frailty after COVID-19. Objectives To investigate frailty …

Post-intensive care syndrome follow-up system after hospital discharge: a narrative review

N Nakanishi, K Liu, J Hatakeyama, A Kawauchi… - Journal of Intensive …, 2024 - Springer
Background Post-intensive care syndrome (PICS) is the long-lasting impairment of physical
functions, cognitive functions, and mental health after intensive care. Although a long-term …

Associations of adverse childhood experiences with frailty in older adults: a cross-sectional analysis of data from the Canadian Longitudinal Study on Aging

O Mian, LN Anderson, DW Belsky, A Gonzalez, J Ma… - Gerontology, 2022 - karger.com
Introduction: Frailty in older adults, characterized by a decline in multiple physiological
systems and increasing vulnerability to loss of independence, disability, and death, is a …

A DNA methylation based measure outperforms circulating CRP as a marker of chronic inflammation and partly reflects the monocytic response to long‐term …

CP Verschoor, C Vlasschaert, MJ Rauh, G Paré - Aging Cell, 2023 - Wiley Online Library
A key hallmark in the age‐related dysfunction of physiological systems is disruption related
to the regulation of inflammation, often resulting in a chronic, low‐grade inflammatory state …