Dendritic cells (DCs) are potent and versatile antigen-presenting cells, and their ability to
migrate is key for the initiation of protective pro-inflammatory as well as tolerogenic immune …

The intestine represents the largest compartment of the immune system. It is continually
exposed to antigens and immunomodulatory agents from the diet and the commensal …

The intestinal immune system is continuously exposed to massive amounts of nanoparticles
derived from food. Whether nanoparticles from plants we eat daily have a role in maintaining …

Gut microbial induction of host immune maturation exemplifies host-microbe mutualism. We
colonized germ-free (GF) mice with mouse microbiota (MMb) or human microbiota (HMb) to …

Sixteen years ago, the Nomenclature Committee of the International Union of Pharmacology
approved a system for naming human seven-transmembrane (7TM) G protein-coupled …

Leukocyte trafficking to the small and large intestines is tightly controlled to maintain
intestinal immune homeostasis, mediate immune responses, and regulate inflammation. A …

Oral tolerance is the state of local and systemic immune unresponsiveness that is induced
by oral administration of innocuous antigen such as food proteins. An analogous but more …

Microbiota-induced cytokine responses participate in gut homeostasis, but the cytokine
balance at steady-state and the role of individual bacterial species in setting the balance …

Several risk factors for Crohn's disease have been identified in recent genome-wide
association studies. To advance gene discovery further, we combined data from three …

The intestinal mucosa is a physiological barrier for most microbes, including both
commensal bacteria and invading pathogens. Under homeostatic conditions …