Recent developments in the use of kinase inhibitors for management of viral infections
R Raghuvanshi, SB Bharate - Journal of medicinal chemistry, 2021 - ACS Publications
Kinases are a group of therapeutic targets involved in the progression of numerous
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …
diseases, including cancer, rheumatoid arthritis, Alzheimer's disease, and viral infections …
Synthesis and Structure–Activity Relationships of 3,5-Disubstituted-pyrrolo[2,3-b]pyridines as Inhibitors of Adaptor-Associated Kinase 1 with Antiviral Activity
There are currently no approved drugs for the treatment of emerging viral infections, such as
dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine–threonine …
dengue and Ebola. Adaptor-associated kinase 1 (AAK1) is a cellular serine–threonine …
An overview of immune evasion strategies of DNA and RNA viruses
SS Naz, A Aslam, T Malik - Infectious Disorders-Drug Targets …, 2021 - ingentaconnect.com
A successful viral infection is due to the effective evasion of viruses of the immune system.
The entry of viruses is usually detected by different cellular receptors including PRRs …
The entry of viruses is usually detected by different cellular receptors including PRRs …
Optimization of Isothiazolo[4,3-b]pyridine-Based Inhibitors of Cyclin G Associated Kinase (GAK) with Broad-Spectrum Antiviral Activity
There is an urgent need for strategies to combat dengue and other emerging viral infections.
We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin …
We reported that cyclin G-associated kinase (GAK), a cellular regulator of the clathrin …
Characterization of a multipurpose NS3 surface patch coordinating HCV replicase assembly and virion morphogenesis
O Isken, MT Pham, H Schwanke, F Schlotthauer… - PLoS …, 2022 - journals.plos.org
The hepatitis C virus (HCV) life cycle is highly regulated and characterized by a step-wise
succession of interactions between viral and host cell proteins resulting in the assembly of …
succession of interactions between viral and host cell proteins resulting in the assembly of …