[HTML][HTML] Review of drug repositioning approaches and resources
Drug discovery is a time-consuming, high-investment, and high-risk process in traditional
drug development. Drug repositioning has become a popular strategy in recent years …
drug development. Drug repositioning has become a popular strategy in recent years …
[HTML][HTML] Artificial intelligence for COVID-19: a systematic review
L Wang, Y Zhang, D Wang, X Tong, T Liu… - Frontiers in …, 2021 - frontiersin.org
Background: Recently, Coronavirus Disease 2019 (COVID-19), caused by severe acute
respiratory syndrome virus 2 (SARS-CoV-2), has affected more than 200 countries and lead …
respiratory syndrome virus 2 (SARS-CoV-2), has affected more than 200 countries and lead …
Drug repurposing in oncology—patient and health systems opportunities
In most countries, healthcare service budgets are not likely to support the current explosion
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …
in the cost of new oncology drugs. Repurposing the large arsenal of approved, non …
Repurposing of drugs: An attractive pharmacological strategy for cancer therapeutics
A Kirtonia, K Gala, SG Fernandes, G Pandya… - Seminars in cancer …, 2021 - Elsevier
Human malignancies are one of the major health-related issues though out the world and
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
anticipated to rise in the future. The development of novel drugs/agents requires a huge …
Trailing TRAIL resistance: novel targets for TRAIL sensitization in cancer cells
Resistance to chemotherapeutic drugs is the major hindrance in the successful cancer
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …
therapy. The tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of …
Repositioning of 8565 existing drugs for COVID-19
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) has infected over 7.1 million people and led to over …
syndrome coronavirus 2 (SARS-CoV-2) has infected over 7.1 million people and led to over …
[HTML][HTML] Nectin4 is a novel TIGIT ligand which combines checkpoint inhibition and tumor specificity
A Reches, Y Ophir, N Stein, I Kol… - … for immunotherapy of …, 2020 - ncbi.nlm.nih.gov
Background The use of checkpoint inhibitors has revolutionized cancer therapy.
Unfortunately, these therapies often cause immune-related adverse effects, largely due to a …
Unfortunately, these therapies often cause immune-related adverse effects, largely due to a …
[HTML][HTML] Drug databases and their contributions to drug repurposing
Drug repurposing is an interesting field in the drug discovery scope because of reducing
time and cost. It is also considered as an appropriate method for finding medications for …
time and cost. It is also considered as an appropriate method for finding medications for …
Blockade of Stearoyl-CoA-desaturase 1 activity reverts resistance to cisplatin in lung cancer stem cells
ME Pisanu, A Noto, C De Vitis, S Morrone… - Cancer letters, 2017 - Elsevier
Poor prognosis in lung cancer has been attributed to the presence of lung cancer stem cells
(CSCs) which resist chemotherapy and cause disease recurrence. Hence, the strong need …
(CSCs) which resist chemotherapy and cause disease recurrence. Hence, the strong need …
Systems biology based drug repositioning for development of cancer therapy
Drug repositioning is a powerful method that can assists the conventional drug discovery
process by using existing drugs for treatment of a disease rather than its original indication …
process by using existing drugs for treatment of a disease rather than its original indication …