The postsynaptic side of the synapse is specialized to receive the neurotransmitter signal
released from the presynaptic terminal and transduce it into electrical and biochemical …

Synaptic dysfunction in CNS disorders is the outcome of perturbations in physiological
synapse structure and function, and can be either the cause or the consequence in specific …

The molecular diversification of cell surface molecules has long been postulated to impart
specific surface identities on neuronal cell types. The existence of unique cell surface …

Cortical circuits are composed predominantly of pyramidal-to-pyramidal neuron
connections, yet their assembly during embryonic development is not well understood. We …

Synapse development requires differentiation of presynaptic neurotransmitter release sites
and postsynaptic receptive apparatus coordinated by synapse organizing proteins. In …

Bassoon and Piccolo are two very large scaffolding proteins of the cytomatrix assembled at
the active zone (CAZ) where neurotransmitter is released. They share regions of high …

Balanced development of excitatory and inhibitory synapses is required for normal brain
function, and an imbalance in this development may underlie the pathogenesis of many …

INTRODUCTION Synapses are fundamental structural and functional units within neural
circuits, where they define the connectivity between neurons and provide avenues for …

Neurexins are well-characterized presynaptic cell adhesion molecules that engage
multifarious postsynaptic ligands and organize diverse synapse properties. However, the …

Neurexins (NXs) and neuroligins (NLs) are transsynaptically interacting cell adhesion
proteins that play a key role in the formation, maturation, activity-dependent validation, and …