Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the …
BA Ference, HN Ginsberg, I Graham… - European heart …, 2017 - academic.oup.com
Aims To appraise the clinical and genetic evidence that low-density lipoproteins (LDLs)
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …
cause atherosclerotic cardiovascular disease (ASCVD). Methods and results We assessed …
F2-Isoprostanes in Human Health and Diseases: From Molecular Mechanisms to Clinical Implications
S Basu - Antioxidants & redox signaling, 2008 - liebertpub.com
Oxidative stress is implicated as one of the major underlying mechanisms behind many
acute and chronic diseases, and involved in normal aging. However, the measurement of …
acute and chronic diseases, and involved in normal aging. However, the measurement of …
Carotid intimal-medial thickness is related to cardiovascular risk factors measured from childhood through middle age: The Muscatine Study
PH Davis, JD Dawson, WA Riley, RM Lauer - Circulation, 2001 - Am Heart Assoc
Background Higher carotid intimal-medial thickness (IMT) is associated with cardiovascular
risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid …
risk factors and is predictive of coronary artery disease and stroke in older adults. Carotid …
[HTML][HTML] Why patients with familial hypercholesterolemia are at high cardiovascular risk? Beyond LDL-C levels
Familial hypercholesterolemia (FH) is a common genetic cause of elevated low-density
lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH …
lipoprotein cholesterol (LDL-C) due to defective clearance of circulating LDL particles. All FH …
The Sirt1 activator SRT3025 provides atheroprotection in Apoe−/− mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression
MX Miranda, LJ Van Tits, C Lohmann… - European heart …, 2015 - academic.oup.com
Abstract Aims The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism,
but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial …
but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial …
Development of sensitive and specific age-and gender-specific low-density lipoprotein cholesterol cutoffs for diagnosis of first-degree relatives with familial …
B Starr, SG Hadfield, BA Hutten… - Clinical chemistry and …, 2008 - degruyter.com
Background: The plasma total and low-density lipoprotein-cholesterol (LDL-C) levels that
are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the …
are used as diagnostic criteria for familial hypercholesterolaemia (FH) probands in the …
Review isoprostanes: novel bioactive products of lipid peroxidation
S Basu - Free radical research, 2004 - Taylor & Francis
Isoprostanes, are a novel group of prostaglandin-like compounds that are biosynthesised
from esterified polyunsaturated fatty acid (PUFA) through a non-enzymatic free radical …
from esterified polyunsaturated fatty acid (PUFA) through a non-enzymatic free radical …
Evaluation of coronary risk factors in patients with heterozygous familial hypercholesterolemia
PN Hopkins, S Stephenson, LL Wu, WA Riley… - The American journal of …, 2001 - Elsevier
Age at onset of clinically manifested coronary artery disease (CAD) varies widely among
patients with familial hypercholesterolemia (FH). A number of factors in addition to high low …
patients with familial hypercholesterolemia (FH). A number of factors in addition to high low …
Prevalence and significance of cardiovascular risk factors in a large cohort of patients with familial hypercholesterolaemia
PRW De Sauvage Nolting, JC Defesche… - Journal of internal …, 2003 - Wiley Online Library
de Sauvage Nolting PRW, Defesche JC, Buirma RJA, Hutten BA, Lansberg PJ, Kastelein
JJP (Academic Medical Center, Amsterdam; Clinical Research, Haarlem; Slotervaart …
JJP (Academic Medical Center, Amsterdam; Clinical Research, Haarlem; Slotervaart …
Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and …
C Masoura, C Pitsavos, K Aznaouridis, I Skoumas… - Atherosclerosis, 2011 - Elsevier
BACKGROUND: To evaluate the impact of familial hypercholesterolemia (FH) and familial
combined hyperlipidemia (FCH) on arterial properties and the effects of statins. METHODS …
combined hyperlipidemia (FCH) on arterial properties and the effects of statins. METHODS …