Malformations of cerebral cortical development include a wide range of developmental
disorders that are common causes of neurodevelopmental delay and epilepsy. In addition …

The homeobox, a 60-amino acid-encoding DNA sequence, originally discovered in the
genome of the fruit fly Drosophila, was subsequently identified throughout the three …

Rieger syndrome (REG) is an autosomal–dominant human disorder that includes anomalies
of the anterior chamber of the eye, dental hypoplasia and a protuberant umbilicus. We report …

ABSTRACT Bone Morphogenetic Proteins (BMPs) play crucial roles in a variety of
developmental processes, but their functions during early vertebrate brain development are …

During early mouse development the homeobox gene Hesx1 is expressed in prospective
forebrain tissue, but later becomes restricted to Rathke's pouch, the primordium of the …

The many recent discoveries concerning the molecular biologic bases of malformations of
cortical development and the discovery of new such malformations have rendered previous …

ABSTRACT The genes Emx1 and Emx2 are mouse cognates of a Drosophila head gap
gene, empty spiracles, and their expression patterns have suggested their involvement in …

For a long time, it has been understood that neurogenesis is linked to proliferation and thus
to the cell cycle. Recently, the gears that mediate this linkage have become accessible to …

Malformations of cortical development (MCDs) are macroscopic or microscopic
abnormalities of the cerebral cortex that arise as a consequence of an interruption to the …

Classical lissencephaly (smooth brain) or generalized agyriapachygyria is a severe brain
malformation which results from an arrest of neuronal migration at 9–13 weeks gestation. It …