Therapeutic strategies for sickle cell disease: towards a multi-agent approach

MJ Telen, P Malik, GM Vercellotti - Nature reviews Drug discovery, 2019 - nature.com
For over 100 years, clinicians and scientists have been unravelling the consequences of the
A to T substitution in the β-globin gene that produces haemoglobin S, which leads to the …

Modeling and prediction of flow-induced hemolysis: a review

MM Faghih, MK Sharp - Biomechanics and modeling in mechanobiology, 2019 - Springer
Despite decades of research related to hemolysis, the accuracy of prediction algorithms for
complex flows leaves much to be desired. Fundamental questions remain about how …

Quantitative analysis of human red blood cell proteome

AH Bryk, JR Wiśniewski - Journal of proteome research, 2017 - ACS Publications
Red blood cells (RBCs) are the most abundant cell type in the human body. RBCs and, in
particular, their plasma membrane composition have been extensively studied for many …

Multiple stiffening effects of nanoscale knobs on human red blood cells infected with Plasmodium falciparum malaria parasite

Y Zhang, C Huang, S Kim… - Proceedings of the …, 2015 - National Acad Sciences
During its asexual development within the red blood cell (RBC), Plasmodium falciparum (Pf),
the most virulent human malaria parasite, exports proteins that modify the host RBC …

A coarse-grained red blood cell membrane model to study stomatocyte-discocyte-echinocyte morphologies

NM Geekiyanage, MA Balanant, E Sauret, S Saha… - PLoS …, 2019 - journals.plos.org
An improved red blood cell (RBC) membrane model is developed based on the bilayer
coupling model (BCM) to accurately predict the complete sequence of stomatocyte-discocyte …

The nutraceuticals as modern key to achieve erythrocyte oxidative stress fighting in osteoarthritis

A Mariano, I Bigioni, F Misiti, L Fattorini… - Current issues in …, 2022 - mdpi.com
Osteoarthritis (OA), the most common joint disease, shows an increasing prevalence in the
aging population in industrialized countries. OA is characterized by low-grade chronic …

How the spleen reshapes and retains young and old red blood cells: A computational investigation

H Li, ZL Liu, L Lu, P Buffet… - PLoS Computational …, 2021 - journals.plos.org
The spleen, the largest secondary lymphoid organ in humans, not only fulfils a broad range
of immune functions, but also plays an important role in red blood cell's (RBC) life cycle …

Protective Effect of Bergapten against Human Erythrocyte Hemolysis and Protein Denaturation In Vitro

DB Aidoo, D Konja, IT Henneh… - International Journal of …, 2021 - Wiley Online Library
Bergapten, a furocoumarin found in many medicinal plants, is used for the management of
various conditions. The present in vitro study evaluated the ability of bergapten to prevent …

Model systems for studying lipid oxidation associated with muscle foods: Methods, challenges, and prospects

H Wu, N Tatiyaborworntham… - Critical Reviews in …, 2024 - Taylor & Francis
Lipid oxidation is a complex process in muscle-based foods (red meat, poultry and fish)
causing severe quality deterioration, eg, off-odors, discoloration, texture defects and …

On the effects of membrane viscosity on transient red blood cell dynamics

F Guglietta, M Behr, L Biferale, G Falcucci… - Soft Matter, 2020 - pubs.rsc.org
Computational Fluid Dynamics (CFD) is currently used to design and improve the hydraulic
properties of biomedical devices, wherein the large scale blood circulation needs to be …